Evidence map›Paper›PMID 33090650›Full record

ArticleNeuromodulation : journal of the International Neuromodulation Society2020

Brain-Derived Neurotrophic Factor Polymorphism Influences Response to Single-Pulse Transcranial Magnetic Stimulation at Rest.

Priyanka Shah-Basak, Denise Y Harvey, Shreya Parchure, Olufunsho Faseyitan, Daniela Sacchetti, Ahmed Ahmed, Abdou Thiam, Falk W Lohoff, Roy H Hamilton

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuromodulation : journal of the International Neuromodulation Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Priyanka Shah-BasakDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA.ORCID https://orcid.org/0000-0003-0763-7381
Denise Y HarveyDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Shreya ParchureDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Olufunsho FaseyitanDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Daniela SacchettiDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Ahmed AhmedDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Abdou ThiamDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Falk W LohoffNational Institute for Alcohol Abuse and Alcoholism, National Institutes of Health (NIH), Bethesda, MD, USA.
Roy H HamiltonDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
University of Pennsylvania · USMedical College of Wisconsin · USMoss Rehabilitation Hospital · USNational Institutes of Health · US

Funding

Postdoctoral Training in Translational Neurorehabilitation ResearchT32HD071844 · NICHD · ALBERT EINSTEIN HEALTHCARE NETWORK · PI WHYTE, JOHN · 2013 to 2022
$2.2M
TMS as a Biomarker of Plasticity in Aphasia RecoveryR01DC012780 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI HAMILTON, ROY H · 2013 to 2017
$1.8M
Dana FoundationNICHD NIH HHS T32 HD071844NIDCD NIH HHS R01 DC012780NINDS NIH HHS 1R01DC012780-01A1
6 · The paper itself

Abstract

objectivesThe ability of noninvasive brain stimulation to modulate corticospinal excitability and plasticity is influenced by genetic predilections such as the coding for brain-derived neurotrophic factor (BDNF). Otherwise healthy individuals presenting with BDNF Val66Met (Val/Met) polymorphism are less susceptible to changes in excitability in response to repetitive transcranial magnetic stimulation (TMS) and paired associative stimulation paradigms, reflecting reduced neuroplasticity, compared to Val homozygotes (Val/Val). In the current study, we investigated whether BDNF polymorphism influences "baseline" excitability under TMS conditions that are not repetitive or plasticity-inducing. Cross-sectional BDNF levels could predict TMS response more generally because of the ongoing plasticity processes. MATERIALS AND

methodsForty-five healthy individuals (23 females; age: 25.3 ± 7.0 years) participated in the study, comprising two groups. Motor evoked potentials (MEP) were collected using single-pulse TMS paradigms at fixed stimulation intensities at 110% of the resting motor threshold in one group, and individually-derived intensities based on MEP sizes of 1 mV in the second group. Functional variant Val66Met (rs6265) was genotyped from saliva samples by a technician blinded to the identity of DNA samples.

resultsTwenty-seven participants (60.0%) were identified with Val/Val, sixteen (35.5%) with Val/Met genotype, and two with Met/Met genotype. MEP amplitudes were significantly diminished in the Val/Met than Val/Val individuals. These results held independent of the single-pulse TMS paradigm of choice (p = 0.017110% group; p = 0.035 1 mV group), age, and scalp-to-coil distances.

conclusionsThe findings should be further substantiated in larger-scale studies. If validated, intrinsic differences by BDNF polymorphism status could index response to TMS prior to implementing plasticity-inducing protocols.

Indexed as

Brain‐derived neurotrophic factormotor excitabilityneuroplasticitypolymorphismssingle‐pulse transcranial magnetic stimulation

Identifiers

PMID33090650
PMCPMC8032803
OpenAlexW3091997777

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.