Evidence map›Paper›PMID 33090643›Full record

ArticleChembiochem : a European journal of chemical biology2021

Metal Ion Promiscuity and Structure of 2,3-Dihydroxybenzoic Acid Decarboxylase of Aspergillus oryzae.

Gerhard Hofer, Xiang Sheng, Simone Braeuer, Stefan E Payer, Katharina Plasch, Walter Goessler, Kurt Faber, Walter Keller, Fahmi Himo, Silvia M Glueck

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Enzymatic Conversion of COChemical reviews · 2023
    Review
  4. The Quantum Chemical Cluster Approach in Biocatalysis.Accounts of chemical research · 2023
    Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Gerhard HoferInstitute of Molecular Biosciences, BioTechMed Graz, University of Graz, 8010, Graz, Austria.ORCID 0000-0002-9248-6989
Xiang ShengDepartment of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691, Stockholm, Sweden.ORCID 0000-0002-6542-6649
Simone BraeuerDepartment of Chemistry, Analytical Chemistry, University of Graz, 8010, Graz, Austria.ORCID 0000-0002-0975-9051
Stefan E PayerDepartment of Chemistry, Organic & Bioorganic Chemistry, University of Graz, 8010, Graz, Austria.ORCID 0000-0001-9665-1710
Katharina PlaschDepartment of Chemistry, Organic & Bioorganic Chemistry, University of Graz, 8010, Graz, Austria.
Walter GoesslerDepartment of Chemistry, Analytical Chemistry, University of Graz, 8010, Graz, Austria.ORCID 0000-0002-0142-9373
Kurt FaberDepartment of Chemistry, Organic & Bioorganic Chemistry, University of Graz, 8010, Graz, Austria.
Walter KellerInstitute of Molecular Biosciences, BioTechMed Graz, University of Graz, 8010, Graz, Austria.ORCID 0000-0002-2261-958X
Fahmi HimoDepartment of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691, Stockholm, Sweden.ORCID 0000-0002-1012-5611
Silvia M GlueckDepartment of Chemistry, Organic & Bioorganic Chemistry, University of Graz, 8010, Graz, Austria.ORCID 0000-0003-2154-7585
University of Graz · ATStockholm University · SE

Funding

Austrian BMWFW, BMVIT, SFG, Standortagentur Tirol, Government of Lower Austria and ZIT I 1637-N19Austrian BMWFW, BMVIT, SFG, Standortagentur Tirol, Government of Lower Austria and ZIT P 26863-N19Helmholtz Association HGFUniversity of Graz F04604
6 · The paper itself

Abstract

Broad substrate tolerance and excellent regioselectivity, as well as independence from sensitive cofactors have established benzoic acid decarboxylases from microbial sources as efficient biocatalysts. Robustness under process conditions makes them particularly attractive for preparative-scale applications. The divalent metal-dependent enzymes are capable of catalyzing the reversible non-oxidative (de)carboxylation of a variety of electron-rich (hetero)aromatic substrates analogously to the chemical Kolbe-Schmitt reaction. Elemental mass spectrometry supported by crystal structure elucidation and quantum chemical calculations verified the presence of a catalytically relevant Mg

Indexed as

Aspergillus oryzaeCarboxy-LyasesCatalysisHydroxybenzoatesKineticsMagnesiumSubstrate SpecificityThermodynamics2,3-dihydroxybenzoic acidCarboxy-LyasesHydroxybenzoatesMagnesiumbiocatalysiscomputational chemistryenzyme structuremetal-identityortho-benzoic acid decarboxylase

Identifiers

PMID33090643
PMCPMC7894528
OpenAlexW3092940994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.