Evidence map›Paper›PMID 33090600›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2021

Synthesis of Asparagine Derivatives Harboring a Lewis X Type DC-SIGN Ligand and Evaluation of their Impact on Immunomodulation in Multiple Sclerosis.

Ward Doelman, Mikkel H S Marqvorsen, Fabrizio Chiodo, Sven C M Bruijns, Gijsbert A van der Marel, Yvette van Kooyk, Sander I van Kasteren, Can Araman

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Synthesis of glycopeptides and glycopeptide conjugates.Organic & biomolecular chemistry · 2022
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ward DoelmanLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-5138-9402
Mikkel H S MarqvorsenLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.ORCID http://orcid.org/0000-0001-8045-7796
Fabrizio ChiodoDepartment of Molecular Cell Biology and Immunology, Amsterdam UMC-Location Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-3619-9982
Sven C M BruijnsDepartment of Molecular Cell Biology and Immunology, Amsterdam UMC-Location Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands.
Gijsbert A van der MarelLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.ORCID http://orcid.org/0000-0001-9577-2123
Yvette van KooykDepartment of Molecular Cell Biology and Immunology, Amsterdam UMC-Location Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-5997-3665
Sander I van KasterenLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-3733-818X
Can AramanLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-6961-5607
Leiden University · NLAmsterdam University Medical Centers · NL

Funding

Lundbeckfonden 2016-2789Nederlandse Organisatie voor Wetenschappelijk Onderzoek 737.016.004
6 · The paper itself

Abstract

The protein myelin oligodendrocyte glycoprotein (MOG) is a key component of myelin and an autoantigen in the disease multiple sclerosis (MS). Post-translational N-glycosylation of Asn

Indexed as

ImmunomodulationAsparagineCell Adhesion MoleculesDC-Specific ICAM-3 Grabbing NonintegrinHumansLectins, C-TypeLigandsMultiple SclerosisMyelin-Oligodendrocyte GlycoproteinReceptors, Cell SurfaceAsparagineCell Adhesion MoleculesDC-Specific ICAM-3 Grabbing NonintegrinLectins, C-TypeLigandsMyelin-Oligodendrocyte GlycoproteinReceptors, Cell Surfacebioorganic chemistryglycoconjugatesglycoimmunologyglycopeptidesmultiple sclerosis

Identifiers

PMID33090600
PMCPMC7898482
OpenAlexW3094305876

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.