ArticleHuman brain mapping2021
Alterations of brain activity and functional connectivity in transition from acute to chronic tinnitus.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- EEG microstates and dynamic functional connectivity reveal stage-specific brain networks in subjective tinnitus.iScience · 2026Article
- Digital twin brain reveals state-specific stimulation targets for abnormal brain dynamics in tinnitus.BMC medicine · 2026Article
- Topological features of brain functional networks are reorganized during chronic tinnitus: A graph-theoretical study.The European journal of neuroscience · 2025Article
- Article
- Tinnitus and dementia risk: a nationwide population-based case-control study.The Journal of laryngology and otology · 2024Article
- Development, Insults and Predisposing Factors of the Brain's Predictive Coding System to Chronic Perceptual Disorders-A Life-Course Examination.Brain sciences · 2024Article
- Functional Connectivity Alterations and Molecular Characterization of the Anterior Cingulate Cortex in Tinnitus Pathology without Hearing Loss.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Abnormal Functional Connectivity Within Default Mode Network and Salience Network Related to Tinnitus Severity.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- Clinical characteristics and psychoacoustic analysis of acute and chronic subjective tinnitus.Laryngoscope investigative otolaryngology · 2023Article
- Role of insula and its subregions in progression from recent onset to chronic idiopathic tinnitus.Brain communications · 2023Article
- Study on tinnitus-related electroencephalogram microstates in patients with vestibular schwannomas.Frontiers in neuroscience · 2023Article
- Long-Term Effects of Repetitive Transcranial Magnetic Stimulation on Tinnitus in a Guinea Pig Model.Brain sciences · 2022Article
- A survey of brain network analysis by electroencephalographic signals.Cognitive neurodynamics · 2022Article
- Recent-onset and persistent tinnitus: Uncovering the differences in brain activities using resting-state functional magnetic resonance imaging technologies.Frontiers in neuroscience · 2022Article
- Pretreatment intranetwork connectivity can predict the outcomes in idiopathic tinnitus patients treated with sound therapy.Human brain mapping · 2021Article
- The balance between Bayesian inference and default mode determines the generation of tinnitus from decreased auditory input: A volume entropy-based study.Human brain mapping · 2021Article
- Methodological Aspects of Randomized Controlled Trials for Tinnitus: A Systematic Review and How a Decision Support System Could Overcome Barriers.Journal of clinical medicine · 2021Review
- Alterations of brain activity and functional connectivity in transition from acute to chronic tinnitus.Human brain mapping · 2021Article
- Acupuncture Treatment Decreased Temporal Variability of Dynamic Functional Connectivity in Chronic Tinnitus.Frontiers in neuroscience · 2021Article
- Aberrant Resting-State Functional Connectivity of the Dorsal Attention Network in Tinnitus.Neural plasticity · 2021Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to investigate alterations to brain activity and functional connectivity in patients with tinnitus, exploring neural features in the transition from acute to chronic phantom perception. Twenty-four patients with acute tinnitus, 23 patients with chronic tinnitus, and 32 healthy controls were recruited. High-density electroencephalography (EEG) was used to explore changes in brain areas and functional connectivity in different groups. When compared with healthy subjects, acute tinnitus patients had a significant reduction in superior frontal cortex activity across all frequency bands, whereas chronic tinnitus patients had a significant reduction in the superior frontal cortex at beta 3 and gamma frequency bands as well as a significant increase in the inferior frontal cortex at delta-band and superior temporal cortex at alpha 1 frequency band. When compared to the chronic tinnitus group, the acute tinnitus group activity was significantly increased in the middle frontal and parietal gyrus at the gamma-band. Functional connectivity analysis showed that the chronic tinnitus group had increased connections between the parahippocampus gyrus, posterior cingulate cortex, and precuneus when compared with the healthy group. Alterations of local brain activity and connections between the parahippocampus gyrus and other nonauditory areas appeared in the transition from acute to chronic tinnitus. This indicates that the appearance and development of tinnitus is a dynamic process involving aberrant local neural activity and abnormal connectivity in multifunctional brain networks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.