Evidence map›Paper›PMID 33090515›Full record

ReviewJournal of medical virology2021

Extrapulmonary manifestations of severe acute respiratory syndrome coronavirus-2 infection.

Hugo R Rosen, Casey O'Connell, Mitra K Nadim, Brittney DeClerck, Sarah Sheibani, Eugene DePasquale, Nerses Sanossian, Emily Blodget, Trevor Angell

Abstract readReview
In one paragraph

Review in Journal of medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Rhabdomyolysis-Induced AKI (RIAKI) Including the Role of COVID-19.International journal of molecular sciences · 2022
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hugo R RosenDepartment of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0002-1110-6914
Casey O'ConnellDepartment of Medicine, University of Southern California, Los Angeles, California, USA.
Mitra K NadimDepartment of Medicine, University of Southern California, Los Angeles, California, USA.
Brittney DeClerckDepartment of Dermatology, University of Southern California, Los Angeles, California, USA.
Sarah SheibaniDepartment of Medicine, University of Southern California, Los Angeles, California, USA.
Eugene DePasqualeDepartment of Medicine, University of Southern California, Los Angeles, California, USA.
Nerses SanossianDepartment of Neurology, University of Southern California, Los Angeles, California, USA.
Emily BlodgetDepartment of Medicine, University of Southern California, Los Angeles, California, USA.
Trevor AngellDepartment of Medicine, University of Southern California, Los Angeles, California, USA.

Funding

USC RESEARCH CENTER FOR LIVER DISEASES: PILOT PROGRAMSP30DK048522 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OOKHTENS, MURAD · 1995 to 2020
$21.8M
Mechanisms of hepatic innate immune activation by HCVR01AI127463 · NIAID · UNIVERSITY OF WASHINGTON · PI GALE, MICHAEL, ROSEN, HUGO RAMON · 2017 to 2021
$2.8M
RESUBMISSION -R01 AI120622 –Restoration of Immunity and Function with DAA Treatment in HCV infectionR01AI120622 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROSEN, HUGO RAMON · 2017 to 2020
$1.6M
Innate Immunity, Cholesterol, and NASH PathogenesisR01DK117004 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GOLDEN, LUCY MARY · 2020 to 2023
$1.5M
NIAID NIH HHS R01 AI120622NIAID NIH HHS R01 AI127463NIDDK NIH HHS P30 DK048522NIDDK NIH HHS R01 DK117004
6 · The paper itself

Abstract

Coronavirus disease 2019, the infectious disease caused by severe acute respiratory syndrome coronavirus-2, has resulted in a global pandemic with unprecedented health, societal, and economic impact. The disease often manifests with flu-like symptoms and is dominated by pulmonary complications, but widely diverse clinical manifestations involving multiple organ systems can result. We posit that viral tropism and the aberrant host immune response mediate the protean findings and severity in this disease. In general, extrapulmonary manifestations are a harbinger of or contemporaneously associate with disease progression, but in the case of some extrapulmonary findings (gastrointestinal and dermatologic), may track with milder disease. The precise underlying pathophysiological mechanisms remain incompletely elucidated, and additional immune phenotyping studies are warranted to reveal early correlates of disease outcomes and novel therapeutic targets.

Indexed as

ImmunityImmunity, InnateCoinfectionCOVID-19HumansPandemicsSARS-CoV-2Viral Tropismgeneralized infectionimmune responseimmune systemimmunopathologyinnate immunitypathogenesis

Identifiers

PMID33090515
PMCPMC7675751

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.