ReviewReproductive sciences (Thousand Oaks, Calif.)2021
Origin and Pathogenic Mechanisms of Uterine Adenomyosis: What Is Known So Far.
Review in Reproductive sciences (Thousand Oaks, Calif.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 63 citations in OpenAlex.
- Role of oral gonadotropin-releasing hormone antagonists in the management of uterine adenomyosis: a narrative review.Reproduction & fertility · 2026Review
- Three-dimensional characterization of adenomyosis in female mice: Toward a novel system for drug efficacy evaluation.Journal of the Endocrine Society · 2026Article
- Identification of Misplaced Endometrial Glands and Stroma in the Myometrium of Foetal Uteri Evocative of Developmental Adenomyosis.International journal of molecular sciences · 2026Article
- Endometrial tuberculosis increases miscarriage risk after IVF/ICSI compared with non-specific chronic endometritis.BMC pregnancy and childbirth · 2026Article
- Shorter Anogenital Distance in Women with Adenomyosis Diagnosed by MUSA 2022 Criteria: A Prospective Case-Control Study.Journal of clinical medicine · 2026Article
- Inflammatory and Molecular Mechanisms of Adenomyosis Associated Pain: Insights from Multiple Analytic Approaches.Journal of pain research · 2026Article
- Temporal dynamics of uterine immune microenvironment remodeling in a murine model of adenomyosis.Molecular human reproduction · 2025Article
- Retrospective cohort study on the efficacy and safety of high-intensity focused ultrasound in non-invasive treatment of uterine leiomyomas and adenomyosis.Abdominal radiology (New York) · 2025Article
- Transitional Lesions, One More Step Towards Understanding the Pathogenesis of Adenomyosis.Journal of clinical medicine · 2025Article
- Risk factors for uterine adenomyosis diagnosed by MRI in women of reproductive age.Annals of medicine and surgery (2012) · 2025Article
- BCL6 (B-cell lymphoma 6) expression in adenomyosis, leiomyomas and normal myometrium.PloS one · 2025Article
- Advances in Adenomyosis Treatment: High-Intensity Focused Ultrasound, Percutaneous Microwave Therapy, and Radiofrequency Ablation.Journal of clinical medicine · 2024Review
- Adenomyosis: An Update Concerning Diagnosis, Treatment, and Fertility.Journal of clinical medicine · 2024Review
- [Role of Notch 1 signaling and glycolysis in the pathogenic mechanism of adenomyosis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Comprehensive transcriptional atlas of human adenomyosis deciphered by the integration of single-cell RNA-sequencing and spatial transcriptomics.Protein & cell · 2024Article
- [Estrogen, estrogen receptor and miR-21 in adenomyosis: their pathogenic roles and regulatory interactions].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Effects of pretreatment strategies on fertility outcomes in patients with adenomyosis.Frontiers in reproductive health · 2024Review
- The Present and the Future of Medical Therapies for Adenomyosis: A Narrative Review.Journal of clinical medicine · 2023Review
- The Role of Platelets in the Pathogenesis and Pathophysiology of Adenomyosis.Journal of clinical medicine · 2023Review
- Functional Implications of Estrogen and Progesterone Receptors Expression in Adenomyosis, Potential Targets for Endocrinological Therapy.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Uterine adenomyosis is a benign disease, commonly encountered in reproductive-age women and responsible for chronic pelvic pain, abnormal uterine bleeding, and infertility. Although the exact origin and pathogenic mechanisms involved in adenomyosis still need to be elucidated, significant progress has been made over recent years. Ever since the theory of endometrium invaginating the myometrium via a traumatized interface was first proposed, numerous molecular mechanisms have been reported to participate in this process. At the same time, an alternative theory has suggested de novo development of adenomyotic lesions from metaplasia of Müllerian remnants or adult stem cells. Hence, our understanding of the pathogenesis of adenomyosis has been greatly enhanced and is anticipated to pave the way for development of an effective and safe treatment. The goal of this review is to analyze current knowledge on the origin and pathogenic mechanisms of adenomyosis, ranging from the most widely accepted theories to newly reported data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.