Evidence map›Paper›PMID 33090349›Full record

ArticleIrish journal of medical science2021

The impact of accurately timed mid-luteal endometrial injury in nulligravid women undergoing their first or second embryo transfer.

David A Crosby, Louise E Glover, Paul Downey, Eoghan E Mooney, Fionnuala M McAuliffe, Cliona O'Farrelly, Donal J Brennan, Mary Wingfield

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Article in Irish journal of medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

David A CrosbyMerrion Fertility Clinic, 60 Mount Street, Dublin 2, Ireland. crosbyd@tcd.ie.
Louise E GloverMerrion Fertility Clinic, 60 Mount Street, Dublin 2, Ireland.
Paul DowneyDepartment of Pathology and Laboratory Medicine, National Maternity Hospital, Dublin, Ireland.
Eoghan E MooneyDepartment of Pathology and Laboratory Medicine, National Maternity Hospital, Dublin, Ireland.
Fionnuala M McAuliffeUCD Obstetrics & Gynaecology, National Maternity Hospital, University College Dublin, Dublin 2, Ireland.
Cliona O'FarrellySchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Donal J BrennanUCD Obstetrics & Gynaecology, National Maternity Hospital, University College Dublin, Dublin 2, Ireland.
Mary WingfieldMerrion Fertility Clinic, 60 Mount Street, Dublin 2, Ireland.

Funding

UCD Wellcome Institutional Strategic Support Fund, which was financed jointly by University College Dublin and the SFI-HRB-Wellcome Biomedical Research Partnership 204833/Z/16/Z
6 · The paper itself

Abstract

introductionEndometrial injury or 'scratch' preceding an assisted reproductive therapy (ART) cycle has recently been shown not to improve livebirth rates among women undergoing ART. The objective of this study was to compare pregnancy outcomes in nulliparous women who underwent an accurately timed mid-luteal scratch biopsy prior to ART with those who did not.

methodsThis was a prospective cohort study. Women were recruited between October 2016 and February 2018 inclusive. Women who met the inclusion criteria and who did not undergo an endometrial scratch in the study period were used as a comparison group. Patients underwent a cycle of ART in the menstrual cycle following endometrial scratch.

resultsNinety-eight women were eligible for participation in the study. There were no differences in rates of implantation (35.7% (n = 20/56) vs. 35.4% (n = 17/48); p = 1.00), clinical pregnancy (40.0% (n = 20/50) vs. 39.5% (n = 17/43); p = 1.00) or live birth (34.0% (n = 17/50) vs. 25.6% (n = 11/43); p = 0.50) per embryo transfer between those who underwent a scratch and those who did not.

conclusionEndometrial scratch is a simple, inexpensive and low-risk procedure. However, in this relatively small cohort study, no differences in rates of implantation, clinical pregnancy or live birth in women with primary infertility were determined between those who underwent a scratch and those who did not.

Indexed as

Embryo TransferFertilization in VitroCohort StudiesFemaleHumansPregnancyPregnancy RateProspective StudiesEndometrial scratchEndometriumPregnancyUnexplained infertility

Identifiers

PMID33090349

What OpenQuestion holds

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