Evidence map›Paper›PMID 33090310›Full record

ArticleAnnals of intensive care2020

Acute respiratory failure in immunocompromised patients: outcome and clinical features according to neutropenia status.

Djamel Mokart, Michael Darmon, Peter Schellongowski, Peter Pickkers, Marcio Soares, Jordi Rello, Philippe R Bauer, Andry van de Louw, Virginie Lemiale, Fabio Silvio Taccone and 19 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of intensive care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Anxiety, worry, and job satisfaction: effects of COVID-19 care on critical care anesthesiologists.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2022
    Article
  9. The impact of the COVID-19 pandemic on intensive care unit workers: a nationwide survey.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2022
    Article
  10. [Cancer patients in the intensive care unit].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 20 institutions in 16 countries.

Djamel MokartRéanimation Polyvalente Et Département D'Anesthésie Et de Réanimation, Institut Paoli-Calmettes, 232 Bd Sainte Marguerite 13009, Marseille Cedex 09, France. mokartd@ipc.unicancer.fr.ORCID http://orcid.org/0000-0003-1711-463X
Michael DarmonMedical Intensive Care Unit, APHP, Hôpital Saint‑Louis, Famirea Study Group, ECSTRA Team and Clinical Epidemiology, UMR 1153, Center of Epidemiology and Biostatistics, Sorbonne Paris Cité, CRESS, INSERM, Paris Diderot Sorbonne University, Paris, France.
Peter SchellongowskiDepartment of Medicine I, Medical University of Vienna, Vienna, Austria.
Peter PickkersThe Department of Intensive Care Medicine (710), Radboud University Medical Center, Nijmegen, The Netherlands.
Marcio SoaresThe Department of Critical Care and Graduate Program in Translational Medicine, D'Or Institute for Research and Education, Programa de Pós-Graduação Em Clínica Médica, Rio de Janeiro, Brazil.
Jordi RelloCIBERES, Instituto de Salud Carlos III, Barcelona, Spain.
Philippe R BauerPulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.
Andry van de LouwDivision of Pulmonary and Critical Care, Penn State University College of Medicine, Hershey, PA, USA.
Virginie LemialeMedical Intensive Care Unit, APHP, Hôpital Saint‑Louis, Famirea Study Group, ECSTRA Team and Clinical Epidemiology, UMR 1153, Center of Epidemiology and Biostatistics, Sorbonne Paris Cité, CRESS, INSERM, Paris Diderot Sorbonne University, Paris, France.
Fabio Silvio TacconeDepartment of Intensive Care, Hôpital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Ignacio Martin-LoechesDepartment of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St. James's Hospital, Dublin, Ireland.
Jorge SalluhThe Department of Critical Care and Graduate Program in Translational Medicine, D'Or Institute for Research and Education, Programa de Pós-Graduação Em Clínica Médica, Rio de Janeiro, Brazil.
Katerina RusinovaDepartment of Anesthesiology and Intensive Care Medicine and Institute for Medical Humanities, 1St Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic.
Sangeeta MehtaDepartment of Medicine and Interdepartmental Division of Critical Care Medicine, Sinai Health System, University of Toronto, Toronto, ON, Canada.
Massimo AntonelliDept of Anesthesia Intensive Care and Emergency Medicine, Fondazione Policlicnico Universitario A.Gemelli IRCCS. Università Cattolica del Sacro Cuore, Rome, Italy.
Achille KouatchetDepartment of Medical Intensive Care Medicine, University Hospital of Angers, Angers, France.
Andreas Barratt-DueDepartment of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway.
Miia ValkonenDivision of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Precious Pearl LandburgDepartment of Critical Care, University Medical Center Groningen, Groningen, The Netherlands.
Ramin Brandt BukanDepartment of Anesthesiology I, Herlev University Hospital, Herlev, Denmark.
Frédéric PèneMedical ICU, Cochin Hospital, Assistance Publique-Hôpitaux de Paris and University Paris Descartes, Paris, France.
Victoria MetaxaKing's College Hospital, London, SE5 9RS, UK.
Gaston BurghiTerapia Intensiva, Hospital Maciel, Montevideo, Uruguay.
Colombe SaillardRéanimation Polyvalente Et Département D'Anesthésie Et de Réanimation, Institut Paoli-Calmettes, 232 Bd Sainte Marguerite 13009, Marseille Cedex 09, France.
Lene B NielsenIntensive Care Department, University of Southern Denmark, Odense, Denmark.
Emmanuel CanetMedical Intensive Care Unit, Hôtel Dieu-HME University Hospital of Nantes, Nantes, France.
Magali BisbalRéanimation Polyvalente Et Département D'Anesthésie Et de Réanimation, Institut Paoli-Calmettes, 232 Bd Sainte Marguerite 13009, Marseille Cedex 09, France.
Elie AzoulayMedical Intensive Care Unit, APHP, Hôpital Saint‑Louis, Famirea Study Group, ECSTRA Team and Clinical Epidemiology, UMR 1153, Center of Epidemiology and Biostatistics, Sorbonne Paris Cité, CRESS, INSERM, Paris Diderot Sorbonne University, Paris, France.
Efraim investigators and the Nine-I study group
Inserm · FRInstitut Paoli-Calmettes · FRD’Or Institute for Research and Education · BRCharles University · CZDélégation Paris 5 · FRHerlev Hospital · DKHospital Maciel · UYInstituto de Salud Carlos III · ESKing's College Hospital · GBMayo Clinic in Florida · USMedical University of Vienna · ATOslo University Hospital · NOPenn State Milton S. Hershey Medical Center · USRadboud University Nijmegen · NLTrinity College Dublin · IEUniversità Cattolica del Sacro Cuore · ITUniversité d'Angers · FRUniversité Libre de Bruxelles · BEUniversity Medical Center Groningen · NLUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe impact of neutropenia in critically ill immunocompromised patients admitted in a context of acute respiratory failure (ARF) remains uncertain. The primary objective was to assess the prognostic impact of neutropenia on outcomes of these patients. Secondary objective was to assess etiology of ARF according to neutropenia.

methodsWe performed a post hoc analysis of a prospective multicenter multinational study from 23 ICUs belonging to the Nine-I network. Between November 2015 and July 2016, all adult immunocompromised patients with ARF admitted to the ICU were included in the study. Adjusted analyses included: (1) a hierarchical model with center as random effect; (2) propensity score (PS) matched cohort; and (3) adjusted analysis in the matched cohort.

resultsOverall, 1481 patients were included in this study of which 165 had neutropenia at ICU admission (11%). ARF etiologies distribution was significantly different between neutropenic and non-neutropenic patients, main etiologies being bacterial pneumonia (48% vs 27% in neutropenic and non-neutropenic patients, respectively). Initial oxygenation strategy was standard supplemental oxygen in 755 patients (51%), high-flow nasal oxygen in 165 (11%), non-invasive ventilation in 202 (14%) and invasive mechanical ventilation in 359 (24%). Before adjustment, hospital mortality was significantly higher in neutropenic patients (54% vs 42%; p = 0.006). After adjustment for confounder and center effect, neutropenia was no longer associated with outcome (OR 1.40, 95% CI 0.93-2.11). Similar results were observed after matching (52% vs 46%, respectively; p = 0.35) and after adjustment in the matched cohort (OR 1.04; 95% CI 0.63-1.72).

conclusionNeutropenia at ICU admission is not associated with hospital mortality in this cohort of critically ill immunocompromised patients admitted for ARF. In neutropenic patients, main ARF etiologies are bacterial and fungal infections.

Identifiers

PMID33090310
PMCPMC7581668
OpenAlexW3094027821

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