Evidence map›Paper›PMID 33090271›Full record

ArticleJournal of neurology2021

Nationwide population-based incidence and etiologies of pediatric and adult Horner syndrome.

Jinu Han, Seong Yong Park, Ju-Yeun Lee

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Horner syndrome in a pediatric patient.Pediatric investigation · 2025
    Article
  2. Article
  3. Cortico-hypothalamic pathway of Horner syndrome derived from isolated lenticulostriate stroke.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Jinu HanInstitute of Vision Research, Gangnam Severance Hospital, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, South Korea.
Seong Yong ParkDepartment of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Seoul, South Korea.
Ju-Yeun LeeDepartment of Ophthalmology, Myongji Hospital, Hanyang University College of Medicine, 55, Hwasu-ro 14, Deogyang-gu, Goyang-si, Gyeonggi-do, 10475, Republic of Korea. leejy5293@gmail.com.ORCID http://orcid.org/0000-0001-7540-7129
Yonsei University · KRNew Generation University College · ET

Funding

"Dongwha" Faculty Research Assistance Program of Yonsei University College of Medicine 6-2017-0169the faculty grant of Myongji Hospital 1902-09-01
6 · The paper itself

Abstract

purposeTo determine age- and sex-specific incidence and possible etiologies of pediatric and adult Horner syndrome in South Korea.

methodsA nationwide, population-based, cohort study using data from the Korean National Health Claims database from 2007 to 2018. All patients with Horner syndrome from the entire Korean population (n = 51,629,512) were included. To find possible causes of Horner syndrome, we searched concurrent codes for systemic diseases, trauma, or surgical procedures.

resultsA total of 139 pediatric patients (59.7% male) and 1331 adults (51.0% male) were newly diagnosed as having Horner syndrome. The cumulative incidence was 2.12 (95% CI 2.08-2.17) per 100,000 pediatric population and 2.95 (2.94-2.96) per 100,000 adults. The peak incidence occurred at 0-4 years of age in the pediatric population, and at 50-54 years in the adult population. A total of 835 (56.8%) patients had underlying conditions or related surgical procedures associated with Horner syndrome. The underlying causes were recognized in 695 (83.2%) patients before the diagnosis of Horner syndrome, in 75 (9.0%) patients at the same time as the Horner syndrome diagnosis, and in 65 (7.8%) patients after the diagnosis of Horner syndrome. There were four cases of Horner syndrome that preceded neuroblastoma diagnosis. The most common tumor related with Horner syndrome was that of the thyroid in the adult population.

conclusionsThis study determined the estimated incidence and possible causes of pediatric and adult Horner syndrome. As Horner syndrome with unknown etiologies may harbor serious malignancy, extensive evaluations are required, especially in children.

Indexed as

Horner SyndromeAdultChildCohort StudiesFemaleHumansIncidenceMaleMiddle AgedRepublic of KoreaRetrospective StudiesCohort studiesHorner syndromeIncidenceNeuro-ophthalmologyRisk factors

Identifiers

PMID33090271
OpenAlexW3093748393

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.