ArticleThe Journal of infectious diseases2021
Impact of Immune Priming, Vaccination, and Infection on Influenza A(H3N2) Antibody Landscapes in Children.
Article in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- A Randomized Controlled Trial to Compare Immunogenicity to Cell-Based Versus Live-Attenuated Influenza Vaccines in Children.Journal of the Pediatric Infectious Diseases Society · 2023Trial
- Trial
- CAPYBARA: A generalizable framework for predicting serological measurements across human cohorts.PLoS computational biology · 2026Article
- The Decline in Influenza Antibody Titers and Modifiers of Vaccine Immunity from over Ten Years of Serological Data.medRxiv : the preprint server for health sciences · 2026Article
- Different antigenic distance metrics generate similar predictions of influenza vaccine response breadth despite moderate correlation.PLoS computational biology · 2025Article
- FLU-v, a Broad-Spectrum Peptide-Based Influenza Vaccine, Induces NK Cell Activating IgG1 and IgG3 Subclass Antibodies in Humans.Vaccines · 2025Article
- Article
- Review
- Breadth of influenza A antibody cross-reactivity varies by virus isolation interval and subtype.Nature microbiology · 2025Article
- Article
- Reconstructed influenza A/H3N2 infection histories reveal variation in incidence and antibody dynamics over the life course.PLoS biology · 2024Article
- Reconstructed influenza A/H3N2 infection histories reveal variation in incidence and antibody dynamics over the life course.medRxiv : the preprint server for health sciences · 2024Article
- Anamnestic broadly reactive antibodies induced by H7N9 virus more efficiently bind to seasonal H3N2 strains.Human vaccines & immunotherapeutics · 2022Article
- Seasonal influenza vaccination expands hemagglutinin-specific antibody breadth to older and future A/H3N2 viruses.NPJ vaccines · 2022Article
- Antibody Responsiveness to Influenza: What Drives It?Viruses · 2021Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPreexisting antibodies to influenza, shaped by early infection and subsequent exposures, may impact responses to influenza vaccination.
methodsWe enrolled 72 children (aged 7-17 years) in 2015-2016; all received inactivated influenza vaccines. Forty-one were also vaccinated in 2014-2015, with 12 becoming infected with A(H3N2) in 2014-2015. Thirty-one children did not have documented influenza exposures in the prior 5 seasons. Sera were collected pre- and postvaccination in both seasons. We constructed antibody landscapes using hemagglutination inhibition antibody titers against 16 A(H3N2) viruses representative of major antigenic clusters that circulated between 1968 and 2015.
resultsThe breadth of the antibody landscapes increased with age. Vaccine-induced antibody responses correlated with boosting of titers to previously encountered antigens. Postvaccination titers were the highest against vaccine antigens rather than the historic A(H3N2) viruses previously encountered. Prevaccination titers to the vaccine were the strongest predictors of postvaccination titers. Responses to vaccine antigens did not differ by likely priming virus. Influenza A(H3N2)-infected children in 2014-2015 had narrower antibody landscapes than those uninfected, but prior season infection status had little effect on antibody landscapes following 2015-2016 vaccination.
conclusionsA(H3N2) antibody landscapes in children were largely determined by age-related immune priming, rather than recent vaccination or infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.