Evidence map›Paper›PMID 33090071›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021

Evaluation of the potassium channel tracer [

Nicolas J Guehl, Karla M Ramos-Torres, Clas Linnman, Sung-Hyun Moon, Maeva Dhaynaut, Moses Q Wilks, Paul K Han, Chao Ma, Ramesh Neelamegam, Yu-Peng Zhou and 7 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 40 citations in OpenAlex.

  1. First evaluation in multiple sclerosis using PET tracer [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Imaging Demyelinated Axons After Spinal Cord Injuries with PET Tracer [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  6. Review
  7. Synthesis of KBioorganic & medicinal chemistry letters · 2024
    Article
  8. Article
  9. PET imaging of M4 muscarinic acetylcholine receptors in rhesus macaques using [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Evaluation ofACS chemical neuroscience · 2023
    Article
  14. Review
  15. Metabolic Stability of the Demyelination Positron Emission Tomography Tracer [The Journal of pharmacology and experimental therapeutics · 2023
    Article
  16. Review
  17. PET imaging studies to investigate functional expression of mGluR2 using [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  18. Radiochemical Synthesis and Evaluation of 3-[ACS chemical neuroscience · 2022
    Article
  19. Synthesis and Characterization of 5-(2-Fluoro-4-[Journal of medicinal chemistry · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Nicolas J GuehlGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Karla M Ramos-TorresGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Clas LinnmanSpaulding Neuroimaging Lab, Spaulding Rehabilitation Hospital and Harvard Medical School, Charlestown, MA, USA.
Sung-Hyun MoonGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Maeva DhaynautGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Moses Q WilksGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Paul K HanGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Chao MaGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Ramesh NeelamegamGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Yu-Peng ZhouGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Brian PopkoDepartment of Neurology, Northwestern Feinberg School of Medicine, Chicago, IL, USA.
John A CorreiaGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Daniel S ReichTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Georges El FakhriGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Peter HerscovitchPositron Emission Tomography Department, NIH Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Marc D NormandinGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Pedro BrugarolasGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-7455-2743
Harvard University · USNational Institutes of Health · USNorthwestern University · US

Funding

Multimodal MRI in Multiple SclerosisZIANS003119 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI REICH, DANIEL · 2010 to 2025
$53.4M
Unified Joint Statistical Reconstruction of PET & MRP41EB022544 · NIBIB · YALE UNIVERSITY · PI Georges El Fakhri · 2017 to 2026
$14.8M
Postgraduate Training Program in Medical Imaging (PTPMI)T32EB013180 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Ciprian Catana, Pedram Heidari · 2011 to 2026
$3.7M
Can [18F]3F4AP Detect Brain Demyelination? Evaluation of Novel PET Tracer in Nonhuman Primates and HumansR01NS114066 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BRUGAROLAS, PEDRO · 2020 to 2024
$1.8M
New tools for imaging: diagnostics based on therapeuticsR00EB020075 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BRUGAROLAS, PEDRO · 2017 to 2019
$747k
Permeability Imaging using Simultaneous Dynamic PET and Arterial Spin Labeling MRIK01EB030045 · NIBIB · YALE UNIVERSITY · PI HAN, PAUL KYU · 2020 to 2023
$497k
Development of a PET radioligand for alpha2delta-1 receptors to visualize and quantify neuropathic pain mechanisms neuropathic pain mechanismsR21NS120139 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BRUGAROLAS, PEDRO · 2020 to 2020
$456k
Gamma counter and continuous blood sampler for quantitative PET imagingS10OD018035 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI EL FAKHRI, GEORGES, NORMANDIN, MARC DAVID · 2014 to 2014
$144k
NIBIB NIH HHS K01 EB030045NIBIB NIH HHS P41 EB022544NIBIB NIH HHS R00 EB020075NIBIB NIH HHS T32 EB013180NIH HHS S10 OD018035NINDS NIH HHS R01 NS114066NINDS NIH HHS R21 NS120139
6 · The paper itself

Abstract

Demyelination causes slowed or failed neuronal conduction and is a driver of disability in multiple sclerosis and other neurological diseases. Currently, the gold standard for imaging demyelination is MRI, but despite its high spatial resolution and sensitivity to demyelinated lesions, it remains challenging to obtain specific and quantitative measures of molecular changes involved in demyelination. To understand the contribution of demyelination in different diseases and to assess the efficacy of myelin-repair therapies, it is critical to develop new in vivo imaging tools sensitive to changes induced by demyelination. Upon demyelination, axonal K

Indexed as

Radioactive TracersAminopyridinesAnimalsBrain InjuriesFluorine RadioisotopesMacaca mulattaMalePositron-Emission TomographyPotassium ChannelsRadiopharmaceuticalsAminopyridinesFluorine-18Fluorine RadioisotopesPotassium ChannelsRadioactive TracersRadiopharmaceuticals[18F]3F4APDemyelinationPET imagingpharmacokineticstraumatic brain injury

Identifiers

PMID33090071
PMCPMC8221756
OpenAlexW3093724233

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.