Evidence map›Paper›PMID 33089916›Full record

ArticleAging cell2020

Plasma proteomic profile of age, health span, and all-cause mortality in older adults.

Sanish Sathyan, Emmeline Ayers, Tina Gao, Erica F Weiss, Sofiya Milman, Joe Verghese, Nir Barzilai

Abstract read
In one paragraph

Article in Aging cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Large-scale circulating proteome association study (CPAS) meta-analysis identifies circulating proteins and pathways predicting incident hip fractures.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Pooled it
  2. Pooled it
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  10. Functional, molecular, and digital measurements of biological age.The Journal of clinical investigation · 2026
    Review
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sanish SathyanDepartment of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID 0000-0002-8127-1835
Emmeline AyersDepartment of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
Tina GaoInstitute for Aging Research, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Erica F WeissDepartment of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
Sofiya MilmanInstitute for Aging Research, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Joe VergheseDepartment of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
Nir BarzilaiInstitute for Aging Research, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID 0000-0002-7787-6268

Funding

Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
Einstein's Nathan Shock Center of Excellence in Basic Biology of AgingP30AG038072 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BARZILAI, NIR J · 2010 to 2024
$10.8M
ROLE OF NUTRIENTS IN AGE-RELATED INSULIN RESISTANCEP01AG021654 · NIA · YESHIVA UNIVERSITY · PI OBICI, SILVANA · 2003 to 2007
$10.6M
Resilience to Alzheimer's disease in humans with exceptional longevityR01AG057909 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BARZILAI, NIR J, ZHANG, ZHENGDONG · 2017 to 2021
$6.2M
Role of exceptional longevity genotypes in protection against frailty in agingR01AG044829 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Sofiya Milman, JOE VERGHESE · 2014 to 2026
$5.4M
Somatotropic Signaling and Resilience to Aging and Alzheimer's DiseaseR01AG061155 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI MILMAN, SOFIYA · 2019 to 2023
$4.3M
LGP/LongenityR01AG046949 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BARZILAI, NIR J · 2013 to 2017
$2.4M
Effect of longevity genomes on the GH/IGF-1 phenotype and disease-free survivalK23AG051148 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MILMAN, SOFIYA · 2015 to 2018
$791k
NIA NIH HHS K23 AG051148NIA NIH HHS P01 AG021654NIA NIH HHS P30 AG038072NIA NIH HHS R01 AG044829NIA NIH HHS R01 AG046949NIA NIH HHS R01 AG057909NIA NIH HHS R01 AG061155NIDDK NIH HHS P30 DK020541
6 · The paper itself

Abstract

Aging is a complex trait characterized by a diverse spectrum of endophenotypes. By utilizing the SomaScan

Indexed as

AgedAgingFemaleHumansMaleMortalityPlasmaProteomicsagingproteomicsSomaScan® assayweighted gene co-expression network analysis

Identifiers

PMID33089916
PMCPMC7681045

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.