ArticleChemistry (Weinheim an der Bergstrasse, Germany)2021
A Straightforward Synthesis of Polyketides via Ester Dienolate Matteson Homologation.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 22 citations in OpenAlex.
- Highly stereoselective synthesis of complex moleculesRSC advances · 2026Article
- Syntheses of Marine Natural Products via Matteson Homologations and Related Processes.Marine drugs · 2025Review
- Synthesis and Late-Stage Modification of (-)-Doliculide Derivatives Using Matteson's Homologation Approach.Marine drugs · 2024Article
- A Straightforward Synthesis of Polyketides via Ester Dienolate Matteson Homologation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
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2 authors at 1 institution in 1 country.
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Abstract
Application of ester dienolates as nucleophiles in Matteson homologations allows for the stereoselective synthesis of highly substituted α,β-unsaturated δ-hydroxy carboxyl acids, structural motifs widespread found in polyketide natural products. The protocol is rather flexible and permits the introduction of substituents and functionalities also at those positions which are not accessible by the commonly used aldol reaction. Therefore, this ester dienolate Matteson approach is an interesting alternative to the "classical" polyketide syntheses.
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