ArticleJournal of neural engineering2020
Computational challenges and opportunities for a bi-directional artificial retina.
Article in Journal of neural engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Fuzzing the brain: automated stress testing for the safety of ML-driven neurostimulation.Journal of neural engineering · 2026Article
- Neural correlates of phosphene perception in blind individuals: A step toward a bidirectional cortical visual prosthesis.Science advances · 2025Article
- Restoration of Sight with Electronic Retinal Prostheses.Annual review of vision science · 2025Review
- Decomposition of retinal ganglion cell electrical images for cell type and functional inference.bioRxiv : the preprint server for biology · 2025Article
- Decoding dynamic visual scenes across the brain hierarchy.PLoS computational biology · 2024Article
- Spike sorting in the presence of stimulation artifacts: a dynamical control systems approach.Journal of neural engineering · 2024Article
- Losing, preserving, and restoring vision from neurodegeneration in the eye.Current biology : CB · 2023Review
- Inferring light responses of primate retinal ganglion cells using intrinsic electrical signatures.Journal of neural engineering · 2023Article
- Electronic Retinal Prostheses.Cold Spring Harbor perspectives in medicine · 2023Review
- Towards aJournal of neural engineering · 2022Article
- Design and Simulation of a Ring Transducer Array for Ultrasound Retinal Stimulation.Micromachines · 2022Article
- Representing the dynamics of high-dimensional data with non-redundant wavelets.Patterns (New York, N.Y.) · 2022Article
- Toward a personalized closed-loop stimulation of the visual cortex: Advances and challenges.Frontiers in cellular neuroscience · 2022Article
- In the Eye of the Storm: Bi-Directional Electrophysiological Investigation of the Intact Retina.Frontiers in neuroscience · 2022Article
- Unraveling neural coding of dynamic natural visual scenes via convolutional recurrent neural networks.Patterns (New York, N.Y.) · 2021Article
- Retinal Ganglion Cells-Diversity of Cell Types and Clinical Relevance.Frontiers in neurology · 2021Review
- Spiking Characteristics of Network-Mediated Responses Arising in Direction-Selective Ganglion Cells of Rabbit and Mouse Retinas to Electric Stimulation for Retinal Prostheses.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A future artificial retina that can restore high acuity vision in blind people will rely on the capability to both read (observe) and write (control) the spiking activity of neurons using an adaptive, bi-directional and high-resolution device. Although current research is focused on overcoming the technical challenges of building and implanting such a device, exploiting its capabilities to achieve more acute visual perception will also require substantial computational advances. Using high-density large-scale recording and stimulation in the primate retina with an ex vivo multi-electrode array lab prototype, we frame several of the major computational problems, and describe current progress and future opportunities in solving them. First, we identify cell types and locations from spontaneous activity in the blind retina, and then efficiently estimate their visual response properties by using a low-dimensional manifold of inter-retina variability learned from a large experimental dataset. Second, we estimate retinal responses to a large collection of relevant electrical stimuli by passing current patterns through an electrode array, spike sorting the resulting recordings and using the results to develop a model of evoked responses. Third, we reproduce the desired responses for a given visual target by temporally dithering a diverse collection of electrical stimuli within the integration time of the visual system. Together, these novel approaches may substantially enhance artificial vision in a next-generation device.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.