Evidence map›Paper›PMID 33089781›Full record

ArticleeLife2020

Structural insight into toxin secretion by contact-dependent growth inhibition transporters.

Jeremy Guerin, Istvan Botos, Zijian Zhang, Karl Lundquist, James C Gumbart, Susan K Buchanan

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. First inhibitor of a bacterial two-partner secretion system.bioRxiv : the preprint server for biology · 2026
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Uncovering the Secretion Systems ofAntibiotics (Basel, Switzerland) · 2023
    Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Protein import and export across the bacterial outer membrane.Current opinion in structural biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jeremy GuerinLaboratory of Molecular Biology, NIDDK, NIH, Bethesda, United States.ORCID 0000-0003-2622-040X
Istvan BotosLaboratory of Molecular Biology, NIDDK, NIH, Bethesda, United States.
Zijian ZhangSchool of Physics, Georgia Institute of Technology, Atlanta, Georgia.
Karl LundquistSchool of Physics, Georgia Institute of Technology, Atlanta, Georgia.
James C GumbartSchool of Physics, Georgia Institute of Technology, Atlanta, Georgia.ORCID 0000-0002-1510-7842
Susan K BuchananLaboratory of Molecular Biology, NIDDK, NIH, Bethesda, United States.ORCID 0000-0001-9657-7119
Georgia Institute of Technology · US

Funding

Dynamic characterization of outer-membrane-protein biogenesis by the BAM and TAM complexesR01GM123169 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI GUMBART, JAMES C. · 2017 to 2021
$1.4M
National Science Foundation MCB-1452464NIGMS NIH HHS R01 GM123169
6 · The paper itself

Abstract

Bacterial contact-dependent growth inhibition (CDI) systems use a type Vb secretion mechanism to export large CdiA toxins across the outer membrane by dedicated outer membrane transporters called CdiB. Here, we report the first crystal structures of two CdiB transporters from

Indexed as

Toxins, BiologicalAcinetobacter baumanniiAmino Acid MotifsEscherichia coliEscherichia coli ProteinsMembrane ProteinsMolecular Dynamics SimulationProtein DomainsCdiA protein, E coliCdiB protein, E coliEscherichia coli ProteinsMembrane ProteinsToxins, Biologicalacinetobacter baumanniibiochemistrychemical biologycontact dependent growth inhibitionE. colimolecular biophysicsOmp85structural biologytoxin secretionTpsBtype V secretion system

Identifiers

PMID33089781
PMCPMC7644211
OpenAlexW3093801148

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.