ArticleeLife2020
An approach for long-term, multi-probe Neuropixels recordings in unrestrained rats.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed.
- SCREWx: A Screwless, Chronic, Recoverable, and Lightweight Neuropixels fixture for freely-moving rodents.bioRxiv : the preprint server for biology · 2026Article
- Density-based longitudinal neuron tracking in high-density electrophysiological recordings.Patterns (New York, N.Y.) · 2026Article
- Hippocampal engrams configure prefrontal context representations to guide flexible decisions.bioRxiv : the preprint server for biology · 2026Article
- A corticostriatal circuit updates subjective beliefs about latent task states.bioRxiv : the preprint server for biology · 2026Article
- Large-scale electrophysiology at single-spike resolution.Nature reviews. Neuroscience · 2026Review
- Sex-specific organization and synaptic signaling in prefrontal-hypothalamic circuitry.bioRxiv : the preprint server for biology · 2026Article
- A Framework for Compressive On-Chip Action Potential Recording.IEEE transactions on bio-medical engineering · 2026Article
- Article
- How distributed is the brain-wide network that is recruited for cognition?Nature reviews. Neuroscience · 2026Review
- Brain-wide coordination of internal signals during decision-making.bioRxiv : the preprint server for biology · 2025Article
- Hierarchical Replay of Multi-regional Sequential Spiking Associated with Working Memory.Neuroscience bulletin · 2025Article
- Article
- The orbitofrontal cortex updates beliefs for state inference.bioRxiv : the preprint server for biology · 2025Article
- Capturing the Electrical Activity of all Cortical Neurons: Are Solutions Within Reach?Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Striatal pathways oppositely shift cortical activity along the decision axis.bioRxiv : the preprint server for biology · 2025Article
- Article
- A reduced ability to discriminate social from non-social touch at the circuit level may underlie social avoidance in autism.Nature communications · 2025Article
- Chronic Probing of Deep Brain Neuronal Activity Using Nanofibrous Smart Conducting Hydrogel-Based Brain-Machine Interface Probes.Small science · 2025Article
- Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The use of Neuropixels probes for chronic neural recordings is in its infancy and initial studies leave questions about long-term stability and probe reusability unaddressed. Here, we demonstrate a new approach for chronic Neuropixels recordings over a period of months in freely moving rats. Our approach allows multiple probes per rat and multiple cycles of probe reuse. We found that hundreds of units could be recorded for multiple months, but that yields depended systematically on anatomical position. Explanted probes displayed a small increase in noise compared to unimplanted probes, but this was insufficient to impair future single-unit recordings. We conclude that cost-effective, multi-region, and multi-probe Neuropixels recordings can be carried out with high yields over multiple months in rats or other similarly sized animals. Our methods and observations may facilitate the standardization of chronic recording from Neuropixels probes in freely moving animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.