Evidence map›Paper›PMID 33089707›Full record

ReviewPostgraduate medicine2022

Potential neurological manifestations of COVID-19: a narrative review.

Joseph V Pergolizzi, Robert B Raffa, Giustino Varrassi, Peter Magnusson, Jo Ann LeQuang, Antonella Paladini, Robert Taylor, Charles Wollmuth, Frank Breve, Maninder Chopra and 3 more

Open access · greenAbstract readReview
In one paragraph

Review in Postgraduate medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. The impact of COVID-19 on chronic pain.Frontiers in pain research (Lausanne, Switzerland) · 2023
    Review
  7. Article
  8. Postural balance and its association with functionality and quality of life in non-hospitalized patients with post-acute COVID-19 syndrome.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2022
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Updates on Palliative Medicine in the COVID-19 Era.Journal of clinical medicine · 2022
    Article
  15. Article
  16. Electrodiagnostic findings in COVID-19 patients: A single center experience.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021
    Observational
  17. Analgesic Drugs and COVID-19.Journal of clinical medicine · 2021
    Article
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 3 countries.

Joseph V PergolizziNEMA Research, Inc., Naples, FL, USA.ORCID 0000-0001-5658-1471
Robert B RaffaTemple University School of Pharmacy, Temple University, Philadelphia, PA, USA.ORCID 0000-0002-1456-4451
Giustino VarrassiPaolo Procacci Foundation, Rome, Italy.ORCID 0000-0002-3822-2923
Peter MagnussonCentre for Research and Development, Region Gävleborg/Uppsala University, Gävle, Sweden.ORCID 0000-0001-7906-7782
Jo Ann LeQuangNEMA Research, Inc., Naples, FL, USA.ORCID 0000-0003-4794-0318
Antonella PaladiniDepartment MESVA, University of L'Aquila, L'Aquila, Italy.ORCID 0000-0002-1219-9315
Robert TaylorNEMA Research, Inc., Naples, FL, USA.ORCID 0000-0001-5971-361X
Charles WollmuthNEMA Research, Inc., Naples, FL, USA.
Frank BreveNEMA Research, Inc., Naples, FL, USA.
Maninder ChopraDecision Alternatives, LLC, Frederick, MD, USA.
Rohit NalamasuDepartment of Physical Medicine and Rehabilitation, University of Nebraska Medical Center, Omaha, NE, USA.
Paul J ChristoDivision of Pain Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
NEMA Research Group
Nema Research (United States) · USFondazione Roma · ITJohns Hopkins University · USUniversity of Arizona · USUniversity of L'Aquila · ITUniversity of Nebraska Medical Center · USUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurological manifestations are increasingly reported in a subset of COVID-19 patients. Previous infections related to coronaviruses, namely Severe Acute Respiratory Syndrome (SARS) and Middle Eastern Respiratory Syndrome (MERS) also appeared to have neurological effects on some patients. The viruses associated with COVID-19 like that of SARS enters the body via the ACE-2 receptors in the central nervous system, which causes the body to balance an immune response against potential damage to nonrenewable cells. A few rare cases of neurological sequelae of SARS and MERS have been reported. A growing body of evidence is accumulating that COVID-19, particularly in severe cases, may have neurological consequences although respiratory symptoms nearly always develop prior to neurological ones. Patients with preexisting neurological conditions may be at elevated risk for COVID-19-associated neurological symptoms. Neurological reports in COVID-19 patients have described encephalopathy, Guillain-Barré syndrome, myopathy, neuromuscular disorders, encephalitis, cephalgia, delirium, critical illness polyneuropathy, and others. Treating neurological symptoms can pose clinical challenges as drugs that suppress immune response may be contraindicated in COVID-19 patients. It is possible that in some COVID-19 patients, neurological symptoms are being overlooked or misinterpreted. To date, neurological manifestations of COVID-19 have been described largely within the disease trajectory and the long-term effects of such manifestations remain unknown.

Indexed as

Brain DiseasesCOVID-19Nervous System DiseasesHumansSARS-CoV-2CoronavirusCOVID-19MERSneurological symptomsSARS

Identifiers

PMID33089707
PMCPMC7799377
OpenAlexW3093534295

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.