ArticleBrain and behavior2021
Positive syphilis serology contributes to intracranial stenosis in ischemic stroke patients.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Stroke and associated comorbidities in Southeast Asian countries.Neuroprotection (Chichester, England) · 2025Review
- Review of the mechanism of infection induced cerebral small vessel disease.Frontiers in immunology · 2025Review
- Acute Ischaemic Stroke in the Context of Neurosyphilis: How Does Antibiotic Therapy Help, and When Should It Be Given?European journal of case reports in internal medicine · 2024Article
- Ischemic strokes revealing neurosyphilis: Study of six (6) observations at the neurology Department of the University Hospital of Conakry.eNeurologicalSci · 2023Article
- MRI of neurosyphilis with mesiotemporal lobe lesions of "knife-cut sign" on MRI: A case report and literature review.Heliyon · 2023Article
- Exploring Stroke Risk Factors and Outcomes in Sexual and Gender Minority People.Neurology. Clinical practice · 2023Article
- Neurosyphilis presenting with focal middle cerebral artery stenosis and acute ischemic stroke: A case report.Radiology case reports · 2022Article
- The associations of increased cerebral small vessel disease with cognitive impairment in neurosyphilis presenting with ischemic stroke.Brain and behavior · 2021Article
- Positive syphilis serology contributes to intracranial stenosis in ischemic stroke patients.Brain and behavior · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe risk of ischemic stroke is increased among people living with syphilis infection; however, whether syphilis is an independently risk for stenosis is unclear. We investigated the clinical, laboratory, and vascular stenosis features of ischemic stroke patients living with positive syphilis serology to evaluate the role of syphilis in cerebral artery stenosis.
methodsThe demographic, clinical characteristics, and the distribution of cerebral artery stenosis were compared between 668 syphilis-positive and 785 syphilis-negative ischemic stroke patients. Multivariate logistic regression analysis was performed to determine the degree and distribution of stenosis associated with positive syphilis serology and estimate the factors related to artery stenosis in the syphilis-positive ischemic stroke patients.
resultsSyphilis-positive ischemic stroke patients were distinct from the nonsyphilis population, with a younger age, fewer women, and a different risk factor profile. Positive syphilis serology was independently associated with moderate stenosis (OR, 2.31; 95% CI 2.02-2.69; p = .003) and severe stenosis (OR, 6.15; 95% CI, 2.85-8.94; p < .001), mainly intracranial stenosis (OR, 1.49; 95% CI, 1.15-1.92; p = .002) rather than extracranial stenosis. Among stroke patients with positive syphilis serology, the higher RPR titer (OR, 1.18, 95% CI, 1.07-1.89 for RPR titer 1:16; OR, 5.16, 95% CI 2.99-8.89 for RPR titer > 1:32) and previous unknown or untreated syphilis (OR, 3.63; 95% CI, 2.72-4.03; p < .001) were the factors related to stenosis.
conclusionsSyphilis infection, especially when less well controlled, may play an important role in intracranial stenosis of ischemic stroke patients.
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