ArticleJournal of cancer survivorship : research and practice2021
Quality of life and mental health in breast cancer survivors compared with non-cancer controls: a study of patient-reported outcomes in the United Kingdom.
Article in Journal of cancer survivorship : research and practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 4 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Recreational physical activity and health-related quality of life among breast cancer survivors: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Pooled it
- Systematic review on the effectiveness of mobile health applications on mental health of breast cancer survivors.Journal of cancer survivorship : research and practice · 2025Pooled it
- The Role of Emotion-Related Abilities in the Quality of Life of Breast Cancer Survivors: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Enhancing Self-Esteem and Body Image of Breast Cancer Women through Interventions: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Profiles of quality of life among US young adult cancer survivors and their associations with potential psychosocial intervention targets of hope and psychological flexibility.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Trial
- Comparison of water- vs. land-based exercise for improving functional capacity and quality of life in patients living with and beyond breast cancer (the AQUA-FiT study): a randomized controlled trial.Breast cancer (Tokyo, Japan) · 2024Trial
- The influence of virtual reality on anxiety and pain in breast cancer patients: A systematic review.Technical innovations & patient support in radiation oncology · 2026Review
- Recruitment Feasibility of Hispanic Women in Breast Cancer Survivorship Research Using State Cancer Registry Procedures.Journal of racial and ethnic health disparities · 2026Article
- Financial toxicity among breast cancer survivors receiving care during the pandemic.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- The CHRONO trial: Protocol for a randomized controlled trial of early time-restricted eating in patients with breast or rectal cancer.Nutrition research (New York, N.Y.) · 2026Article
- User Perspectives on a Clinical Decision Tool to Support Individualized Exercise Prescriptions for Breast Cancer Survivors Not Meeting Exercise Guidelines: Cross-Sectional Survey.JMIR formative research · 2026Article
- Gender role in radiotherapy: psychosocial differences between males and females during cancer care : Single-centre report on adult and paediatric oncological patients.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026Article
- Quality of life, healthcare usage and finances of UK cancer survivors five years post-diagnosis: a matched controlled study.Journal of cancer survivorship : research and practice · 2026Article
- The moderating and mediating effects of mindful compassion with body-mind-spirit therapy using a blended approach of face-to-face with online for breast cancer patients' depression during COVID-19: A randomized controlled trial.Internet interventions · 2026Article
- Factors associated with health-related quality of life in survivors of childhood-onset and adult-onset cancer compared to controls.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Extracting Quality of Life Information of Patients Diagnosed With Breast Cancer From Health Care Online Forum Posts: Data Feasibility Study.JMIR cancer · 2026Article
- Multimodal Cancer Therapy and Accelerated Brain Aging: Mechanisms, Biomarkers, and Clinical Consequences.Current oncology (Toronto, Ont.) · 2026Review
- Modern Personalized Strategies for Breast Cancer Treatment: Bridging Precision Oncology and Psycho-Oncology.Journal of clinical medicine · 2026Review
- Time-Resolved Fluorescence and Diffuse Reflectance (TRF-DR) Spectroscopy for Heterogeneous Breast Tissue Classification and Tumor Margin Assessment.Journal of biophotonics · 2026Article
- Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
purposeThere is limited high-quality evidence on quality of life, anxiety, and depressive symptoms in breast cancer survivors and women with no history of cancer. We aimed to address this by comparing patient-reported outcomes between breast cancer survivors and women with no history of breast cancer.
methodsBreast cancer survivors and women with no prior cancer were selected from the UK Clinical Practice Research Datalink GOLD primary care database, which includes population-based primary care electronic health record data. Breast cancer survivors and controls were frequency matched by age and primary care practice. Outcomes were assessed with validated instruments via postal questionnaire. Linear and logistic regression models were fitted to estimate adjusted associations between breast cancer survivorship and outcomes.
resultsA total of 356 breast cancer survivors (8.1 years post diagnosis) and 252 women with no prior cancer participated in the study. Compared with non-cancer controls, breast cancer survivors had poorer QoL in the domains of cognitive problems (adjusted β (aβ) = 1.4, p = 0.01), sexual function (aβ = 1.7, p = 0.02) and fatigue (aβ = 1.3, p = 0.01), but no difference in negative feelings, positive feelings, pain, or social avoidance. Breast cancer survivors had higher odds of borderline-probable anxiety (score ≥ 8) (adjusted OR = 1.47, 95%CI:1.15-1.87), but no differences in depression. Advanced stage at diagnosis and chemotherapy treatment were associated with poorer QoL.
conclusionsCompared with women with no history of cancer, breast cancer survivors report more problems with cognition, sexual function, fatigue, and anxiety, particularly where their cancer was advanced and/or treated with chemotherapy. IMPLICATIONS FOR CANCER SURVIVORS: Breast cancer survivors with more advanced disease and/or treated with chemotherapy should be closely monitored and, when possible, offered evidence-based intervention for fatigue, cognitive dysfunction, and sexual problems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.