SynthesisTranslational stroke research2021
Increased Stroke Risk in Metabolically Abnormal Normal Weight: a 10-Year Follow-up of 102,037 Participants in China.
Synthesis in Translational stroke research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Risk of Stroke Among Different Metabolic Obesity Phenotypes: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Immune Consequences of Metabolic Syndrome and Its Treatment: A Cytokine Perspective.Immunology · 2026Article
- Dynamic associations of BMI-metabolic phenotype transitions with incident cardiovascular disease in middle-aged and elderly adults: a longitudinal cohort study.BMC cardiovascular disorders · 2026Article
- Correlation analysis between eight anthropometric indicators and arterial stiffness in relatively healthy Chinese adults.Frontiers in nutrition · 2026Article
- The relationship between arthritis and mild cognitive impairment in different obese metabolic heterogeneity populations-the mediating role of depression.Frontiers in nutrition · 2026Article
- Association between the C-reactive protein-triglyceride glucose index and new-onset coronary heart disease among metabolically heterogeneous individuals.Cardiovascular diabetology · 2025Article
- Identification of causal plasma metabolite biomarkers for ischemic stroke using Mendelian randomization and mediation analysis.Scientific reports · 2025Article
- Association between triglyceride-glucose index and the risk of type 2 diabetes mellitus.Archives of endocrinology and metabolism · 2025Article
- The impact of metabolic heterogeneity of obesity and transitions on cardiovascular disease incidence in Chinese middle-aged and elderly population: A nationwide prospective cohort study.Diabetes, obesity & metabolism · 2025Article
- Potential roles of cigarette smoking on gut microbiota profile among Chinese men.BMC medicine · 2025Article
- Metabolic obesity phenotypes and risk of ischemic stroke: The Rural Chinese Cohort Study.Frontiers in nutrition · 2025Article
- Relationships among the triglyceride-glucose index, its changes, and the development of metabolically obese normal weight are strengthened by increased visceral fat area.Frontiers in nutrition · 2025Article
- Associations Between Obesity-Related Metabolic Phenotypes, Metabolic Transitions, and Cognitive Function in Middle-Aged and Older Adults in China.Journal of multidisciplinary healthcare · 2025Article
- Association between the triglyceride-glucose (TyG) index and stroke risk in Chinese normal-weight adults: a population-based study.Diabetology & metabolic syndrome · 2024Article
- PMHeliyon · 2024Article
- Healthy lifestyle decreases the risk of the first incidence of non-communicable chronic disease and its progression to multimorbidity and its mediating roles of metabolic components: a prospective cohort study in China.The journal of nutrition, health & aging · 2024Article
- China stroke surveillance report 2021.Military Medical Research · 2023Review
- Associations of metabolic heterogeneity of obesity with frailty progression: Results from two prospective cohorts.Journal of cachexia, sarcopenia and muscle · 2023Article
- Sex Differences in the TyG Index and Cardiovascular Risk Factors in Metabolically Obese Normal Weight Phenotype.International journal of endocrinology · 2022Article
- Traditional Chinese Medicine Monomers: Novel Strategy for Endogenous Neural Stem Cells Activation After Stroke.Frontiers in cellular neuroscience · 2021Review
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to investigate the risks of stroke in subjects with metabolically abnormal normal weight (MANW) in China. We recruited 102,037 participants from the Zhejiang Metabolic Syndrome Cohort and the Kailuan cohort. The mean years of follow-up were 9.9 years. General obesity was defined by body mass index (BMI) ≥ 28, overweight by BMI < 28 and ≥ 24, and normal weight by BMI < 24 and ≥ 18.5. Metabolic abnormality was defined as two or more abnormal components (elevated triglycerides, low high-density lipoprotein cholesterol, elevated systolic blood pressure or diastolic blood pressure, or use of antihypertensive drug therapy, elevated fasting plasma glucose, or antidiabetic treatment). A multiple Cox regression model was used to calculate hazard ratio (HR) and its 95% confidence interval (CI), adjusted by potential confounding factors. Overall HR of the risks in two cohorts was calculated by a meta-analysis. Compared with the subjects who were metabolically normal with normal weight (MNNW), the pooled HR for stroke in MANW subjects was 1.82 (95% CI, 1.59-2.07). The risks of stroke in MANW subjects were significantly lower than that in subjects with metabolically abnormal obesity (MAO), but higher than that in those with metabolically normal obesity (MNO) (P < 0.05). These associations remained in the subtypes of cerebral infarction and cerebral hemorrhage. In normal-weight subjects, the HR for stroke was significantly positively correlated with the number of abnormal metabolic components (P
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