Evidence map›Paper›PMID 33089453›Full record

ArticleStem cell reviews and reports2021

Mesenchymal Stem Cells: a Potential Treatment Approach for Refractory Chronic Spontaneous Urticaria.

Rabia Bilge Özgül Özdemir, Alper Tunga Özdemir, Cengiz Kırmaz, Ercüment Ovalı, Ercüment Ölmez, Hakan Kerem, Mustafa Kürşat Evrenos, Günnur Deniz

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Article in Stem cell reviews and reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Rabia Bilge Özgül ÖzdemirDepartment of Allergy and Clinical Immunology, Manisa City Hospital, Manisa, Turkey.ORCID 0000-0002-8171-3402
Alper Tunga ÖzdemirDepartment of Medical Biochemistry, Merkezefendi State Hospital, Manisa, Turkey. alpertungaozdemir@outlook.com.ORCID 0000-0002-7708-077X
Cengiz KırmazMedical School, Department of Allergy and Clinical Immunology, Manisa Celal Bayar University, Manisa, Turkey.ORCID 0000-0001-8873-1681
Ercüment OvalıMedical School, Department of Internal Medicine, Division of Hematology, Acıbadem University, Istanbul, Turkey.ORCID 0000-0002-4782-5355
Ercüment ÖlmezMedical School, Department of Pharmacology, Manisa Celal Bayar University, Manisa, Turkey.ORCID 0000-0003-3535-2471
Hakan KeremMedical School, Department of Plastic Surgery, Manisa Celal Bayar University, Manisa, Turkey.ORCID 0000-0003-0429-2736
Mustafa Kürşat EvrenosMedical School, Department of Plastic Surgery, Manisa Celal Bayar University, Manisa, Turkey.ORCID 0000-0001-9784-0193
Günnur DenizAziz Sancar Institute of Experimental Medicine, Department of Immunology, Istanbul University, Istanbul, Turkey.ORCID 0000-0002-0721-6213
Manisa Celal Bayar University · TRAcıbadem University · TRIstanbul University · TRIzmir University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The etiopathogenesis of chronic spontaneous urticaria (CSU) is not fully elucidated, and almost 30-40% of patients are resistant to treatments; therefore, there is still a need for the development of new and effective treatments. This study aimed to develop experimental cellular therapy for CSU patients resistant to current treatment options. Autologous adipose tissue mesenchymal stem cells (MSC) were administered to 10 refractory CSU patients who were then followed up for six months. The efficacy of treatment was evaluated according to the weekly urticaria activity scores (UAS7) and drug use scores (DUS7). To observe the effect of treatment on immune cells, CD4

Indexed as

Chronic UrticariaMesenchymal Stem CellsDinoprostoneHumansTransforming Growth Factor beta1DinoprostoneTransforming Growth Factor beta1AutoimmunityChronic spontaneous urticariaImmunomodulationMesenchymal stem cellsT helper cells

Identifiers

PMID33089453
OpenAlexW3094135742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.