Evidence map›Paper›PMID 33089447›Full record

SynthesisNeurosurgical review2021

Glioma surgery with awake language mapping versus generalized anesthesia: a systematic review.

Ling-Hao Bu, Jie Zhang, Jun-Feng Lu, Jin-Song Wu

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neurosurgical review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 7 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 7 syntheses or guidelines pooled it, 64 citations in OpenAlex.

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  19. Passive functional mapping of receptive language cortex during general anesthesia using electrocorticography.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ling-Hao BuDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Jie ZhangDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China. zhang_jie11@fudan.edu.cn.ORCID http://orcid.org/0000-0002-6805-8474
Jun-Feng LuDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Jin-Song WuDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Fudan University · CN

Funding

National Natural Science Foundation of China No.81701289Shanghai Municipal Science and Technology Major Project No.2018SHZDZX01Shanghai Shen Kang Hospital Development Center SHDC12018114
6 · The paper itself

Abstract

Awake craniotomy with language mapping is being increasingly applied to avoid postoperative language dysfunctions worldwide. However, the effectiveness and reliability of this technique remain unclear due to the paucity of studies comparing the awake craniotomy with general anesthesia. To determine the benefit of awake craniotomy for language, motor, and neurological functions, as well as other clinical outcomes, we searched Medline, Embase, the Cochrane Library, and the Chinese Biomedical Literature Database up to December 2019. Gray literatures were also searched. We included randomized and non-randomized controlled studies comparing awake craniotomy versus general anesthetic resection and reporting the language and neurological outcomes. Ten studies with 833 patients were included in the meta-analysis. The pooled risk ratio (RR) suggested no significant differences in language and neurological outcomes between general anesthesia group and awake craniotomy group without electrical stimulation. Awake craniotomy with electrical stimulation, however, was associated with improved late language and neurological outcomes (≥ 3 months) versus general anesthesia with pooled RR of 0.44 (95% CI = 0.20-0.96) and 0.49 (95% CI = 0.30-0.79), respectively. Awake craniotomy with electrical stimulation was also associated with better extent of resection with the pooled RR of 0.81 (95%CI = 0.71-0.92) and shorter hospital stay duration with the pooled weighted mean difference (WMD) of - 1.14 (95%CI = - 1.80 to - 0.48). This meta-analysis suggested that the application of awake craniotomy with electrical stimulation during glioma resection is associated with lower risks of long-term neurological and language deficits and higher extent of tumor resection, as well as shorter hospital stay duration.

Indexed as

Brain NeoplasmsGliomaAnesthesia, GeneralBrain MappingCraniotomyHumansLanguageReproducibility of ResultsWakefulnessAwake craniotomyElectrical stimulationLanguage mappingSystematic review

Identifiers

PMID33089447
OpenAlexW3094017136

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.