Evidence map›Paper›PMID 33089387›Full record

Observational studyEuropean journal of pediatrics2021

Prevalence and risk factors of lactic acidosis in children with acute moderate and severe asthma, a prospective observational study.

Marta Ruman-Colombier, Isabelle Rochat Guignard, Ermindo R Di Paolo, Mario Gehri, Jean-Yves Pauchard

Erratum issuedOpen access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Lactate in Anaphylaxis: 100 Years On.Sports medicine (Auckland, N.Z.) · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. The more you give, the worse it gets.Breathe (Sheffield, England) · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Marta Ruman-ColombierChildren's Hospital, Service of Paediatrics, Department of Woman, Mother, Child, Lausanne University Hospital, University of Lausanne, Chemin de Montétan 16, 1004, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-2841-5956
Isabelle Rochat GuignardRespiratory Unit, Service of Paediatrics, Department of Woman, Mother, Child, Lausanne University Hospital, University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
Ermindo R Di PaoloService of Pharmacy, Lausanne University Hospital, University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
Mario GehriChildren's Hospital, Service of Paediatrics, Department of Woman, Mother, Child, Lausanne University Hospital, University of Lausanne, Chemin de Montétan 16, 1004, Lausanne, Switzerland.
Jean-Yves PauchardChildren's Hospital, Service of Paediatrics, Department of Woman, Mother, Child, Lausanne University Hospital, University of Lausanne, Chemin de Montétan 16, 1004, Lausanne, Switzerland. jean-yves.pauchard@chuv.ch.
University of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lactic acidosis is a common complication of status asthmaticus in adults. However, data is sparse in children. The aim of this study was to describe the prevalence and risk factors for lactic acidosis in children hospitalised for acute moderate or severe asthma. A total of 154 children 2-17 years of age were enrolled in a prospective observational study conducted in a tertiary hospital. All had capillary blood gas assessment 4 h after the first dose of salbutamol in hospital. The primary endpoint was the prevalence of lactic acidosis. Potential contributing factors such as age, sex, BMI, initial degree of asthma severity, type of salbutamol administration (nebuliser or inhaler), steroids, ipratropium bromide, and glucose-containing maintenance fluid represented secondary endpoints. All in all, 87% of patients had hyperlactatemia (lactate concentration > 2.2 mmol/l). Lactic acidosis (lactate concentration > 5 mmol/l and anion gap ≥ 16 mmol/l) was observed in 26%. In multivariate analysis, age more than 6 years (OR = 2.8, 95% CI 1.2-6.6), glycemia above 11 mmol/l (OR = 3.2 95% CI 1.4-7.4), and salbutamol administered by nebuliser (OR = 10, 95% CI 2.7-47) were identified as risk factors for lactic acidosis in children with moderate or severe asthma.Conclusion: Lactic acidosis is a frequent and early complication of acute moderate or severe asthma in children. What is Known: • Lactic acidosis during acute asthma is associated with b2-mimetics administration. • Salbutamol-related lactic acidosis is self-limited but important to recognise, as compensatory hyperventilation of lactic acidosis can be mistaken for respiratory worsening and lead to inappropriate supplemental bronchodilator administration. What is New: • Lactic acidosis is a frequent complication of acute asthma in the paediatric population. • Age older than 6 years, hyperglycaemia, and nebulised salbutamol are risk factors for lactic acidosis during asthma.

Indexed as

Acidosis, LacticAsthmaAdolescentAlbuterolChildChild, PreschoolHumansPrevalenceRisk FactorsAlbuterolAsthmaLactic acidosisPaediatricsSalbutamol

Identifiers

PMID33089387
PMCPMC7940309
OpenAlexW3094410571

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.