ArticleMikrochimica acta2020
Photoelectrochemical aptasensor with low background noise.
Article in Mikrochimica acta, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 7 citations in OpenAlex.
- Dual-functional probe for sensitive detection of MCF-7 cells and mendelian randomization analysis of MUC1 association with multiple cancers.Scientific reports · 2025Article
- Laser ablative TiOMikrochimica acta · 2022Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
In photoelectrochemical (PEC) detection, enhancing the PEC signal and depressing the blank signal are conducive to improve the sensitivity. Because the carbon nanotube (CNT) effectively transfers photogenerated electrons from SnSe to the electrode, the composite nanomaterial CNTs/SnSe generates a strong PEC signal. Methionine (Met), AuNPs, and probe DNA are woven together forming a nanoprobe which is used as a quencher to quench the PEC signal of CNTs/SnSe. When the nanoprobe and CNTs/SnSe are modified onto the electrode, there is a low blank signal. In the presence of metastatic breast cancer cells, the cells interact with the aptamer of dsDNA; concomitantly, cDNA is released to trigger catalytic hairpin assembly (CHA). As a result, a new dsDNA which has an overhang is formed. The nanoprobe on the surface of the electrode hybridizes with the newly formed dsDNA. Subsequently, the nanoprobe is released from the surface of the electrode and the quenching effect between the nanoprobe and the CNTs/SnSe disappears. The PEC aptasensor is linear in the concentration range of 300-5,000 cells/mL, and the detection limit is 180 cells/mL under optimized conditions. The relative standard deviation (RSD) is 3.6% at 10,000 cells/mL. This work demonstrates a promising strategy using CNTs/SnSe as the photoactive material and Met-AuNPs as the quencher to establish a PEC aptasensor with a high PEC response and low blank signal. It can be used to detect bioactive substances at ultralow levels prospectively. Graphical abstract.
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Registered trials
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