ReviewClocks & sleep2019
Sleep Modelling across Physiological Levels.
Review in Clocks & sleep, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Zebrafish sleep displays distinct sub-states.iScience · 2026Article
- Zebrafish sleep displays distinct sub-states.bioRxiv : the preprint server for biology · 2025Article
- Understanding sleep health challenges of defence shift workers to design a digital, sleep and circadian management tool.Scientific reports · 2025Article
- Impact of Varying Sleep Pressure on Daytime Sleep Propensity in Healthy Young and Older Adults.Clocks & sleep · 2025Article
- Mapping the physiological changes in sleep regulation across infancy and young childhood.PLoS computational biology · 2024Article
- SleepSync: Early Testing of a Personalised Sleep-Wake Management Smartphone Application for Improving Sleep and Cognitive Fitness in Defence Shift Workers.Clocks & sleep · 2024Article
- Cortical waste clearance in normal and restricted sleep with potential runaway tau buildup in Alzheimer's disease.Scientific reports · 2022Article
- The 5-HT and PLC Signaling Pathways Regulate the Secretion of IL-1Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Circadian rhythms and the HPA axis: A systems view.WIREs mechanisms of disease · 2021Review
- Selection of stimulus parameters for enhancing slow wave sleep events with a neural-field theory thalamocortical model.PLoS computational biology · 2021Article
- Recent advances in modeling sleep: from the clinic to society and disease.Current opinion in physiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep and circadian rhythms are regulated across multiple functional, spatial and temporal levels: from genes to networks of coupled neurons and glial cells, to large scale brain dynamics and behaviour. The dynamics at each of these levels are complex and the interaction between the levels is even more so, so research have mostly focused on interactions within the levels to understand the underlying mechanisms-the so-called reductionist approach. Mathematical models were developed to test theories of sleep regulation and guide new experiments at each of these levels and have become an integral part of the field. The advantage of modelling, however, is that it allows us to simulate and test the dynamics of complex biological systems and thus provides a tool to investigate the connections between the different levels and study the system as a whole. In this paper I review key models of sleep developed at different physiological levels and discuss the potential for an integrated systems biology approach for sleep regulation across these levels. I also highlight the necessity of building mechanistic connections between models of sleep and circadian rhythms across these levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.