Evidence map›Paper›PMID 33089149›Full record

ArticleAnnals of pancreatic cancer2019

Evolving trends in pancreatic cancer therapeutic development.

Imani Bijou, Jin Wang

Open access · diamondAbstract read
In one paragraph

Article in Annals of pancreatic cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Three-dimensional analysis of human pancreatic cancer specimens by phase-contrast based X-ray tomography - the next dimension of diagnosis.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Imani BijouDepartment of Pharmacology and Chemical Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.
Jin WangDepartment of Pharmacology and Chemical Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.
Baylor College of Medicine · US

Funding

Initiative for Maximizing Student Development (IMSD) ProgramR25GM056929 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI PEREIRA, FRED A · 1998 to 2023
$12.4M
Targeting a lipid-mediated pro-longevity pathway as Alzheimer's therapyRF1AG062257 · NIA · BAYLOR COLLEGE OF MEDICINE · PI WANG, JIN, WANG, MENG CARLA · 2018 to 2020
$4.0M
Reversible Covalent BTK Degraders as the Next Generation Targeted Therapy to Treat B-cell MalignanciesR01CA250503 · NCI · BAYLOR COLLEGE OF MEDICINE · PI WANG, JIN, WANG, MICHAEL · 2020 to 2024
$3.4M
Drugging the Undruggable Coactivators using Small Molecule InhibitorsR01CA207701 · NCI · BAYLOR COLLEGE OF MEDICINE · PI WANG, JIN · 2017 to 2021
$2.5M
REAL-TIME QUANTITATIVE IMAGING OF INTRACELLULAR BIOTHIOL DYNAMICSR01GM115622 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI WANG, JIN · 2015 to 2019
$1.6M
Engineering Antibody Drug Conjugates To Target P53-Defective Triple Negative Breast CancerR21CA213535 · NCI · BAYLOR COLLEGE OF MEDICINE · PI LU, XIONGBIN, WANG, JIN · 2017 to 2018
$394k
NCI NIH HHS R01 CA207701NCI NIH HHS R01 CA250503NCI NIH HHS R21 CA213535NIA NIH HHS RF1 AG062257NIGMS NIH HHS R01 GM115622NIGMS NIH HHS R25 GM056929
6 · The paper itself

Abstract

Despite advances in translational research, the overall 5-year survival for pancreatic cancer remains dismal and with rising incidence pancreatic cancer is predicted to be the second leading cause of cancer death for many developed countries. Surgical intervention followed by cytotoxic chemotherapy are currently the best options for treatment, but disease recurrence is very common. Efforts to develop new therapeutic agents and delivery systems are necessary to achieve better clinical efficacy with less toxicity. Promising prospects are arising with new preclinical and clinical therapeutic strategies using small molecule targeted therapies, RNAi, stromal therapies, and immunotherapies. With a better understanding of the biology to aid target selection and discovery of biomarkers to aid precision medicine, better opportunities will evolve to shape the therapeutic landscape, enhance patient quality of life and increase overall survival.

Indexed as

chemotherapyPancreatic cancerpersonalized medicinetargeted therapy

Identifiers

PMID33089149
PMCPMC7575122
OpenAlexW2982125364

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.