Evidence map›Paper›PMID 33089121›Full record

ArticleEClinicalMedicine2020

Treatments for infantile Hemangioma: A systematic review and network meta-analysis.

Qiang Fei, Yu Lin, Xian Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Effective Management of Tongue Hemangioma Using Boiling 3% Hypertonic Saline Injections: A Case Report from a Resource-Limited Setting.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Qiang FeiDepartment of Pediatrics, The Children's Hospital of Zhejiang University School of Medicine, No.3333, Binsheng Rd, Hangzhou 310003, China.
Yu LinDepartment of Pediatrics, The Children's Hospital of Zhejiang University School of Medicine, No.3333, Binsheng Rd, Hangzhou 310003, China.
Xian ChenDepartment of Pediatrics, The Children's Hospital of Zhejiang University School of Medicine, No.3333, Binsheng Rd, Hangzhou 310003, China.
Children's Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInfantile hemangioma (IH) is common in children, which may bring about cosmetically disfiguring, functional impairment, and exhibiting complications. There had been various therapies and we aimed to assess the efficacy and adverse effects of different therapies through network meta-analysis.

methodsWe searched PubMed, Embase, Cochrane Library and Web of Science (from database inception to April 11, 2020) for studies assessing the efficacy, success rate and adverse effects. Direct pairwise comparison and a network meta-analysis under random effects were performed. We also assessed the ranking probability.

findingsA total of 30 randomized clinical trials with more than 20 different therapeutic regimens were identified. Treatment combined propranolol orally with laser could improve the curative effect than monotherapy. Laser with topical β blockers showed more efficiency than others whether in children under 6 months or not. The long-pulsed dye laser might be the best laser therapy. A higher dose and a longer treatment duration of propranolol orally achieved a higher success rate and increased side effects. Plus pulse dye laser with propranolol had the lowest incidence of adverse reactions, such as ulcer, color sink and color reduction.

interpretationA combination of β blockers and laser might be the first-line treatment of IHs and a longer pulsed dye laser is preferred.

fundingNo funding was received.

Indexed as

ATL, atenololCAP, captoprilCI, confidence intervalsH, a higher doseHemangiomaIH, infantile hemangiomaIMQ, imiquimodL, a longer treatment durationLaser, PDL and Nd:YAG laserLPDL, PDL at a long pulse durationNd, Nd:YAG laserNetwork meta-analysisNMA, network meta-analysisOR, odds ratiosPDL, pulsed dye laserPED, prednisonePRO, propranololRCT, randomized clinical trialsS, a shorter treatment durationSUCRA, surface under the cumulative ranking curveTA, triamcinoloneTherapeuticsβ, topical β-blockers treatment

Identifiers

PMID33089121
PMCPMC7565185
OpenAlexW3049350582

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.