ArticleEuropean heart journal. Case reports2020
Successful treatment of acute heart failure in COVID-19-induced cytokine storm with tocilizumab: a case report.
Article in European heart journal. Case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 23 citations in OpenAlex.
- Research progress on the association between viruses and cardiac diseases.Journal of virology · 2026Review
- LINC00963 targeting miR-98-5p exacerbates sepsis-induced myocardial injury.Internal and emergency medicine · 2026Article
- Case Report: A case of heart failure recovery after non-ischemic cardiomyopathy following chimeric antigen receptor T-cell therapy.Frontiers in cardiovascular medicine · 2025Article
- Review
- Fulminant Myocarditis with SARS-CoV-2 Infection: A Narrative Review from the Case Studies.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2024Review
- Fulminant Myocarditis and Cardiogenic Shock Following COVID-19 Infection Versus COVID-19 Vaccination: A Systematic Literature Review.Journal of clinical medicine · 2023Article
- Impact of COVID-19 on Cardiovascular Disease.Viruses · 2023Review
- Takotsubo Cardiomyopathy and COVID-19: A Case Report and Literature Review.Current cardiology reviews · 2023Review
- Clinical variants of myocardial involvement in COVID-19-positive patients: a cumulative experience of 2020.Heart failure reviews · 2022Review
- The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury.JACC. Basic to translational science · 2022Review
- Severe acute heart failure during or following cytokine release syndrome after CAR T-cell therapy.Leukemia research reports · 2022Article
- Heart Failure Relapses in Response to Acute Stresses - Role of Immunological and Inflammatory Pathways.Frontiers in cardiovascular medicine · 2022Review
- Characteristics of Takotsubo cardiomyopathy in patients with COVID-19: Systematic scoping review.American heart journal plus : cardiology research and practice · 2022Article
- COVID-19 Induced Cardiomyopathy Successfully Treated with Tocilizumab.Case reports in cardiology · 2022Article
- Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19.International journal of molecular sciences · 2021Article
- Genomic variation, origin tracing, and vaccine development of SARS-CoV-2: A systematic review.Innovation (Cambridge (Mass.)) · 2021Review
- Acute Circulatory Collapse and Advanced Therapies in Patients with COVID-19 Infection.Methodist DeBakey cardiovascular journal · 2021Review
- Catecholamine-Induced Secondary Takotsubo Syndrome in Children With Severe Enterovirus 71 Infection and Acute Heart Failure: A 20-year Experience of a Single Institute.Frontiers in cardiovascular medicine · 2021Article
- Vagus Nerve Stimulation: A Potential Adjunct Therapy for COVID-19.Frontiers in medicine · 2021Article
- Takotsubo Syndrome a Rare Entity in COVID-19: a Systemic Review-Focus on Biomarkers, Imaging, Treatment, and Outcome.SN comprehensive clinical medicine · 2021Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSARS-CoV-2 is known to induce a cytokine storm, a hyperinflammatory state driven by up-regulation of interleukin 6 (IL-6) and immunomodulatory chemokines that may result in acute heart failure. CASE SUMMARY: A 65-year-old woman with confirmed SARS-CoV-2 developed shock with multiorgan system failure, including acute biventricular heart failure, 2 weeks after the initial onset of fever, cough, and shortness of breath. The patient experienced myocardial recovery within 48 h after administration of tocilizumab, a humanized monoclonal anti-IL-6 receptor antibody, and multiple supportive vasoactive medications. DISCUSSION: The differential diagnosis of acute heart failure in critically ill patients with COVID-19 infection is broad, including sepsis-induced cardiomyopathy, Takotsubo syndrome, viral lymphocytic myocarditis, and acute coronary syndrome. Immunomodulatory treatment with tocilizumab may benefit patients who develop cardiogenic shock associated with SARS-CoV-2-induced cytokine storm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.