Evidence map›Paper›PMID 33088906›Full record

ArticleAmerican journal of medical case reports2020

Anti-N-methyl-d-aspartate Receptor Encephalitis Related Sinus Node Dysfunction and the Lock-Step Phenomenon.

Krunal H Patel, Yuvraj Chowdhury, Mrinali Shetty, Vaibhavi Uppin, Paul Madaj, Moro O Salifu, Mary Youssef, Victoria L Henglein, Samy I McFaralne

Open access · diamondAbstract read
In one paragraph

Article in American journal of medical case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Anti-NMDA receptor encephalitis associated with severe sinoatrial node dysfunction: three case reports and a review of the literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Krunal H PatelDepartment of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY, USA - 11203.
Yuvraj ChowdhuryDivision of Cardiovascular Disease, State University of New York, Downstate Medical Center, Brooklyn, NY, USA - 11203.
Mrinali ShettyDivision of Cardiovascular Disease, University of Chicago (NorthShore), Evanston, IL, USA - 60201.
Vaibhavi UppinDivision of Cardiovascular Disease, State University of New York, Downstate Medical Center, Brooklyn, NY, USA - 11203.
Paul MadajDivision of Cardiovascular Disease, State University of New York, Downstate Medical Center, Brooklyn, NY, USA - 11203.
Moro O SalifuDepartment of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY, USA - 11203.
Mary YoussefDepartment of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY, USA - 11203.
Victoria L HengleinDepartment of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY, USA - 11203.
Samy I McFaralneDepartment of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY, USA - 11203.
SUNY Downstate Health Sciences University · USNorthShore University HealthSystem · US

Funding

TRANSPORT - the TRANSlational Program Of health disparities Research TrainingS21MD012474 · NIMHD · SUNY DOWNSTATE MEDICAL CENTER · PI Carla Boutin-Foster, William Marcus Lambert · 2017 to 2026
$18.0M
NIMHD NIH HHS S21 MD012474
6 · The paper itself

Abstract

Described in 2007, anti-N-methyl-d-aspartate receptor encephalitis (ANMDARE) is a rare autoimmune limbic encephalitis affecting young adults (predominantly women of reproductive age) and is a paraneoplastic manifestation of ovarian teratoma in about half of the cases. ANMDARE is characterized by psychiatric changes, neurological changes, autonomic instability and cardiac dysrhythmias. In this report, we present a 36-year-old woman who was 16 weeks pregnant and brought to the hospital with confusion and subsequently had a seizure with Electroencephalography (EEG) demonstrated an extreme delta brush pattern consistent with ANMDARE. Patient developed sinus nodal dysfunction and was also found to have ovarian teratoma, a rather typical presentation for ANMDARE, that is considered a paraneoplastic syndrome for ovarian teratoma. In this report, we highlight the cardiac manifestation of ANMDARE, the pathophysiology associated with autonomic instability, and management strategies of this rare, and largely devastating illness.

Indexed as

anti-N-methyl-d-aspartate receptor encephalitis (ANMDARE)autoimmune encephalitisautonomic dysregulationLock Step Phenomenonovarian teratomasinus node dysfunction

Identifiers

PMID33088906
PMCPMC7575203
OpenAlexW3087778298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.