ArticleInternational journal of cardiology. Heart & vasculature2020
Anatomical characteristics of anomalous left coronary artery from the opposite sinus (left-ACAOS) and its clinical relevance: A serial coronary CT angiography study.
Article in International journal of cardiology. Heart & vasculature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Single Coronary Artery in the Context of Vascular Disease: Anatomy, Development, Multimodality Imaging, and Clinical Interpretation.Journal of clinical medicine · 2026Review
- [Anomalous origin of the left anterior descending artery from the right coronary artery: A case report].Revista medica del Instituto Mexicano del Seguro Social · 2026Article
- Inferior Wall STEMI Resulting from Anomalous Origin of Right Coronary Artery from Left Coronary Sinus.Acta Cardiologica Sinica · 2025Article
- Navigating the Uncommon: PCI to an Anomalous Right Coronary Artery With a Malignant Course Following Failed Arterial Grafts.Case reports in cardiology · 2025Article
- Anatomical Variants of the Origin of the Coronary Arteries: A Systematic Review and Meta-Analysis of Prevalence.Diagnostics (Basel, Switzerland) · 2024Review
- Type II single coronary artery from right aortic sinus, retro-aortic left coronary artery and dual LAD: a rare association of coronary arterial variations.Surgical and radiologic anatomy : SRA · 2023Article
- Variation of computed tomographic angiography-based fractional flow reserve after transcatheter aortic valve implantation.European radiology · 2021Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnomalous left coronary artery from the opposite sinus (left-ACAOS) is a rare congenital heart disease. While "interarterial course" is considered as the malignant anatomic feature for these patients, a number of patients with left-ACAOS, who don't follow the above anatomic pattern, were reported with ischemic symptoms. PURPOSE: This study aims to evaluate the anatomic characteristics of left-ACAOS and their clinical relevance.
methodsThe coronary computed tomography angiography (CCTA) data from 44 patients with 46 left-ACAOS vessels were retrospectively included. Patients were divided into 2 groups: those with ischemic symptoms (n = 19) and those without ischemic symptoms (n = 25). Baseline clinical characteristics were recorded and the follow-up was done by telephone. CCTA images were reviewed for anomalous coronary artery, take-off angle and level, ostia morphology and grading, proximal narrowing, anomalous course and atherosclerotic plaques.
resultsThe prevalence of left-ACAOS was approximately 0.09% among 48, 719 consecutive patients referred for coronary CTA in our institution. Right sinus of Valsalva (RSV) was the most common origin (36/46, 78.26%). Left-ACAOS arising from right coronary artery (RCA) had narrower proximal segment (P = 0.014) and more prone to atherosclerosis (P = 0.040) than left-ACAOS arising from right sinus of Valsalva (RSV). Proximal narrowing severity (P < 0.001) and degree of maximal coronary stenosis (P = 0.034) of the anomalous left artery was higher in patients with ischemic symptoms than those without. Of note, no MACE was recorded during a mean follow-up of 43.4 ± 26.2 months.
conclusionLeft-ACAOS arising from RCA seems to be more prone to atherosclerosis than other subtypes. Proximal narrowing was more severe in patients with ischemia symptoms, which may contribute to risk stratification and clinical management.
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