ArticleBone reports2020
The mortality burden of non-trauma fracture for adults with cerebral palsy.
Article in Bone reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Cerebral Palsy and Postoperative Outcomes After Distal Radius Fracture Repair: A Retrospective Analysis.Journal of hand surgery global online · 2026Article
- Longitudinal Patterns of Postfracture Outpatient Physical Therapy and Occupational Therapy Use and Its Association With 3-Year Mortality Among Adults With Cerebral Palsy.Physical therapy · 2023Article
- Article
- 5-year fracture risk among children with cerebral palsy.Pediatric research · 2023Article
- Post-fracture rehabilitation pathways and association with mortality among adults with cerebral palsy.Clinical rehabilitation · 2023Article
- Risk of post-fracture pneumonia and its association with cardiovascular events and mortality in adults with intellectual disabilities.Frontiers in psychiatry · 2023Article
- Five-year risk of fracture and subsequent fractures among adults with cerebral palsy.Bone reports · 2022Article
- Post-Fracture Inpatient and Outpatient Physical/Occupational Therapy and Its Association with Survival among Adults with Cerebral Palsy.Journal of clinical medicine · 2022Article
- Physical and occupational therapy utilization and associated factors among adults with cerebral palsy: Longitudinal modelling to capture distinct utilization groups.Disability and health journal · 2022Article
- Excess healthcare spending associated with fractures among adults with cerebral palsy.Disability and health journal · 2022Article
- Article
- Preventive Care for Adults With Cerebral Palsy and Other Neurodevelopmental Disabilities: Are We Missing the Point?Frontiers in integrative neuroscience · 2022Article
- Navigating the Pathway to Care in Adults With Cerebral Palsy.Frontiers in neurology · 2021Review
- Shared Physiologic Pathways Among Comorbidities for Adults With Cerebral Palsy.Frontiers in neurology · 2021Article
- The Effect of Osteoporosis Medication on Risk Attenuation of Non-Trauma Fracture Among Adults with Cerebral Palsy: A Propensity Score-Matched Observational Study.Clinical epidemiology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIndividuals with cerebral palsy (CP) manifest skeletal fragility problems early in life, are vulnerable to non-trauma fracture (NTFx), and have a high burden of premature mortality. No studies have examined the contribution of NTFx to mortality among adults with CP. The purpose of this study was to determine if NTFx is a risk factor for mortality among adults with CP and if NTFx exacerbates mortality risk compared to adults without CP.
methodsData from 2011 to 2016 Optum Clinformatics® Data Mart and a random 20% sample Medicare fee-for-service were used for this retrospective cohort study. Diagnosis codes were used to identify adults (18+ years) with and without CP, NTFx, and pre-NTFx comorbidities. Crude mortality rates per 100 person years were estimated. Cox regression estimated hazard ratios (HR and 95% confidence interval [CI]) for mortality, comparing: (1) CP and NTFx (CP + NTFx;
resultsThe 3-, 6-, and 12-month crude mortality rates were highest among CP + NTFx (12-month mortality rate = 6.80), followed by w/o CP + NTFx (12-month mortality rate = 4.91), CP w/o NTFx (12-month mortality rate = 2.15), and w/o CP w/o NTFx (12-month mortality rate = 0.49). After adjustments, the mortality rate was elevated for CP + NTFx for all time points compared to CP w/o NTFx (e.g., 12-month HR = 1.61; 95%CI = 1.29-2.01), w/o CP + NTFx (e.g., 12-month HR = 1.49; 95%CI = 1.24-1.80), and w/o CP w/o NTFx (e.g., 12-month HR = 5.33; 95%CI = 4.42-6.44). There were site-specific effects (vertebral column, lower extremities) on 12-month mortality.
conclusionsNTFx is associated with an increase of 12-month mortality risk among adults with CP and compared to adults without CP. Findings suggest that NTFx may be a robust risk factor for mortality among adults with CP.
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