Evidence map›Paper›PMID 33088694›Full record

ArticleActa pharmaceutica Sinica. B2020

Inhibition of post-trabeculectomy fibrosis

Kuan Jiang, Junyi Chen, Lingyu Tai, Chang Liu, Xishan Chen, Gang Wei, Weiyue Lu, Weisan Pan

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Kuan JiangKey Laboratory of Smart Drug Delivery, Ministry of Education; Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China.
Junyi ChenDepartment of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.
Lingyu TaiKey Laboratory of Smart Drug Delivery, Ministry of Education; Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China.
Chang LiuKey Laboratory of Smart Drug Delivery, Ministry of Education; Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China.
Xishan ChenKey Laboratory of Smart Drug Delivery, Ministry of Education; Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China.
Gang WeiKey Laboratory of Smart Drug Delivery, Ministry of Education; Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China.
Weiyue LuKey Laboratory of Smart Drug Delivery, Ministry of Education; Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China.
Weisan PanSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Fudan University · CNEye & ENT Hospital of Fudan University · CNShenyang Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trabeculectomy is the mainstay of surgical glaucoma treatment, while the success rate was unsatisfying due to postoperative scarring of the filtering blebs. Clinical countermeasures for scar prevention are intraoperative intervention or repeated subconjunctival injections. Herein, we designed a co-delivery system capable of transporting fluorouracil and anti-TGF-

Indexed as

ASO, antisense oligonucleotideDAPI, 4′,6-diamidino-2-phenylindoleDLS, dynamic light scatteringEE, encapsulation efficiencyEGF, epidermal growth factorFAM, 6-carboxyfluoresceinFBS, fetal bovine serumFibrosis preventionFITC, fluorescein 5-isothiocyanateFluorouracilFu, fluorouracilGAPDH, glyceraldehyde-3-phosphate dehydrogenaseGene deliveryHA, hyaluronic acidHRP, horseradish peroxidaseIBAGS, the Indiana Bleb Appearance Grading ScaleIOP, intraocular pressureL929, murine fibroblast cellsMWCO, molecular weight cut-offPAGE, polyacrylamide gel electrophoresisPAMAM, poly(amidoamine)PEI, polyethyleniminePene, penetratinPenetratinPG5, PAMAM G5–NH2PLGA, poly(lactic-co-glycolic acid)PVDF, polyvinylidene difluorideSDHCEC, human corneal epithelial cellsSDS, sodium dodecyl sulfateTEM, transmission electron microscopeTGF-β, transforming growth factor-βTrabeculectomy

Identifiers

PMID33088694
PMCPMC7563997
OpenAlexW3013974115

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.