Evidence map›Paper›PMID 33088693›Full record

ArticleActa pharmaceutica Sinica. B2020

A combination of LightOn gene expression system and tumor microenvironment-responsive nanoparticle delivery system for targeted breast cancer therapy.

Xinyu Hou, Chenting Shou, Muye He, Jiajun Xu, Yi Cheng, Zeting Yuan, Minbo Lan, Yuzheng Zhao, Yi Yang, Xianjun Chen and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Xinyu HouShanghai Key Laboratory of New Drug Design, East China University of Science and Technology, Shanghai 200237, China.
Chenting ShouDepartment of Pharmaceutics, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Muye HeDepartment of Pharmaceutics, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Jiajun XuDepartment of Pharmaceutics, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Yi ChengDepartment of Pharmaceutics, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Zeting YuanDepartment of Pharmaceutics, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Minbo LanShanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, China.
Yuzheng ZhaoShanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, China.
Yi YangShanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, China.
Xianjun ChenShanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, China.
Feng GaoShanghai Key Laboratory of New Drug Design, East China University of Science and Technology, Shanghai 200237, China.
East China University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A light-switchable transgene system called LightOn gene expression system could regulate gene expression with a high on/off ratio under blue light, and have great potential for spatiotemporally controllable gene expression. We developed a nanoparticle drug delivery system (NDDS) to achieve tumor microenvironment-responsive and targeted delivery of diphtheria toxin A (DTA) fragment-encoded plasmids to tumor sites. The expression of DTA was induced by exposure to blue light. Nanoparticles composed of polyethylenimine and vitamin E succinate linked by a disulfide bond, and PEGylated hyaluronic acid modified with RGD peptide, accumulated in tumor tissues and were actively internalized into 4T1 cells

Indexed as

Breast cancerDiphtheria toxinLight-switchable gene expression systemMicroenvironment-responsiveNanoparticle drug delivery system

Identifiers

PMID33088693
PMCPMC7564032
OpenAlexW3020404814

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.