Evidence map›Paper›PMID 33088692›Full record

ArticleActa pharmaceutica Sinica. B2020

Remote loading paclitaxel-doxorubicin prodrug into liposomes for cancer combination therapy.

Jiang Yu, Yingli Wang, Shuang Zhou, Jinbo Li, Jiamei Wang, Dongxu Chi, Xue Wang, Guimei Lin, Zhonggui He, Yongjun Wang

Open access · diamondAbstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 98 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jiang YuWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
Yingli WangWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
Shuang ZhouWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
Jinbo LiWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
Jiamei WangWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
Dongxu ChiDepartment of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
Xue WangDepartment of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
Guimei LinSchool of Pharmaceutical Science, Shandong University, Jinan 250012, China.
Zhonggui HeWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
Yongjun WangWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
Shenyang Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The combination of paclitaxel (PTX) and doxorubicin (DOX) has been widely used in the clinic. However, it remains unsatisfied due to the generation of severe toxicity. Previously, we have successfully synthesized a prodrug PTX-

Indexed as

ALT, alanine transaminaseAST, aspartate transaminaseAUC, area under the curveBUN, blood urea nitrogenCHO, cholesterolCO2, carbon dioxideCombination therapyCR, creatinineCu2+, copper ionsDL, drug loadingDLS, dynamic light scatteringDMSO, dimethyl sulfoxideDNA, deoxyribonucleic acidDOX, doxorubicinDSPE-PEG2000, 2-distearoyl-snglycero-3-phosphoethanolamine-N-[methyl(polyethylene glycol)-2000DTT, d,l-dithiothreitolEDTA, ethylene diamine tetraacetic acidEE, encapsulation efficacyFBS, fetal bovine serumGSH, glutathioneH2O2, hydrogen peroxideH&E, hematoxylin and eosinHEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acidHPLC, high-performance liquid chromatographyHSPC, hydrogenated soybean phospholipidsIC50, half maximal inhibitory concentrationIVIS, in vivo imaging systemMLVs, multilamellar vesiclesMRT, mean residence timeMTD, maximum tolerated doseMTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideNanoparticlesPaclitaxel–doxorubicin prodrugPBS, phosphate buffer salinePDI, polydispersity indexProdrugPSD LPs, PTX-S-DOX liposomesPSD NPs, PTX-S-DOX self-assembled nanoparticlesPSD, PTX-S-DOXPTX, paclitaxelRemote loading liposomesROS, reactive oxygen speciesSafetySD, standard deviationTEM, transmission electron microscopyUV, ultraviolet

Identifiers

PMID33088692
PMCPMC7564015
OpenAlexW3017933082

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.