Evidence map›Paper›PMID 33088496›Full record

ReviewJRSM cardiovascular disease

Galactin-3 and soluble ST2 as complementary tools to cardiac MRI for sudden cardiac death risk stratification in heart failure: A review.

Niel N Shah, Puvanalingam Ayyadurai, Muhammad Saad, Constantine E Kosmas, Muhammad U Dogar, Upen Patel, Timothy J Vittorio

Open access · bronzeAbstract readReview
In one paragraph

Review in JRSM cardiovascular disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Advances in biomarkers for myocardial injury after non-cardiac surgery.Journal of anesthesia and translational medicine · 2026
    Review
  3. Transition to Advanced Heart Failure: From Identification to Improving Prognosis.Journal of cardiovascular development and disease · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Niel N ShahDepartment of Medicine, BronxCare Health System/BronxCare Hospital Center, Bronx, NY, USA.
Puvanalingam AyyaduraiDepartment of Medicine, BronxCare Health System/BronxCare Hospital Center, Bronx, NY, USA.ORCID https://orcid.org/0000-0001-7927-655X
Muhammad SaadDepartment of Medicine, BronxCare Health System/BronxCare Hospital Center, Bronx, NY, USA.ORCID https://orcid.org/0000-0002-3827-2218
Constantine E KosmasDepartment of Medicine, Division of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Muhammad U DogarDepartment of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Upen PatelDepartment of Medicine, Nassau University Medical Center, East Meadow, NY, USA.
Timothy J VittorioDepartment of Medicine, BronxCare Health System/BronxCare Hospital Center, Bronx, NY, USA.
MemorialCare Health System · USIcahn School of Medicine at Mount Sinai · USNassau University Medical Center · USSUNY Downstate Health Sciences University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart failure (HF) is recognized as one of the leading causes of morbidity and mortality worldwide. Every year about 500,000 new cases of HF are diagnosed in the United States. The predominant etiology of death in HF patients include sudden cardiac death (SCD) and pump failure. Prediction of mode of death may help in devising management decisions. In patients with HF, the presence of myocardial fibrosis has been a known risk factor for SCD and thus it could be used as a criterion in risk stratification for SCD. However, the underlying pathophysiology of SCD is uncertain and controversial, which makes it necessary to develop newer tools to enhance SCD risk stratification. The newer tools should be innovative enough either to complement or to replace the currently available tools. In this scoping review, we highlighted the utilization of novel biomarkers galectin-3 (gal-3) and soluble ST2 (sST2) and discussed that how they might complement currently available tools such as, cardiac MRI (CMR) for SCD risk stratification in HF patients.

Indexed as

cardiac magnetic resonanceheart failureSudden cardiac death

Identifiers

PMID33088496
PMCPMC7545756
OpenAlexW3087939016

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.