ArticleOncotarget2020
Deconstructing tumor heterogeneity: the stromal perspective.
Open access · diamondAbstract read
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Article in Oncotarget, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Scalable, generalizable and uncertainty-aware integration of spatial multiomics across diverse modalities and platforms with SCIGMA.Nature genetics · 2026Article
- Patient-specific lung cancer tumoroids recapitulate the tumor microenvironments for functional evaluation of therapeutic responses and immune-stromal interactions.Journal of translational medicine · 2026Article
- Harnessing Cancer Stem Cells and 3D Organoids in Unravelling Spatial and Cellular Heterogeneity in Cancer.International journal of molecular sciences · 2026Review
- Preclinical screening models in anticancer drug development: strengths, limitations, and translational challenges.Frontiers in pharmacology · 2026Review
- Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer.Cancer cell · 2025Article
- Sympathetic nerve signaling rewires the tumor microenvironment: a shift in "microenvironmental-ity".Cancer metastasis reviews · 2025Review
- Reprogramming of normal fibroblasts into ovarian cancer-associated fibroblasts via non-vesicular paracrine signaling induces an activated fibroblast phenotype.Biochimica et biophysica acta. Molecular cell research · 2024Article
- Article
- Ovarian Cancer Cell-Conditioning Medium Induces Cancer-Associated Fibroblast Phenoconversion through Glucose-Dependent Inhibition of Autophagy.International journal of molecular sciences · 2024Article
- Prognostic Value of miR-10a-3p in Non-Small Cell Lung Cancer Patients.OncoTargets and therapy · 2024Article
- Spatial immune composition of tumor microenvironment in patients with pancreatic cancer.Cancer immunology, immunotherapy : CII · 2023Article
- Sexually dimorphic effect of H-ferritin genetic manipulation on survival and tumor microenvironment in a mouse model of glioblastoma.Journal of neuro-oncology · 2023Article
- Nanomedicine Strategies for Targeting Tumor Stroma.Cancers · 2023Review
- Targeting fibroblast activation protein (FAP): advances in CAR-T cell, antibody, and vaccine in cancer immunotherapy.Drug delivery and translational research · 2023Review
- Activated fibroblasts in cancer: Perspectives and challenges.Cancer cell · 2023Review
- Cancer-associated fibroblasts: The chief architect in the tumor microenvironment.Frontiers in cell and developmental biology · 2023Review
- Identification of stromal microenvironment characteristics and key molecular mining in pancreatic cancer.Discover oncology · 2022Article
- Review
- Targeting HIF-2α in the Tumor Microenvironment: Redefining the Role of HIF-2α for Solid Cancer Therapy.Cancers · 2022Review
- Fibroblast heterogeneity in prostate carcinogenesis.Cancer letters · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 20 institutions in 3 countries.
Renee E VickmanDepartment of Surgery, NorthShore University HealthSystem, Evanston, IL, USA.
Douglas V FagetDepartment of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, MO, USA.
Philip BeachyDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.
David BeebeDepartment of Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, USA.
Neil A BhowmickDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Edna CukiermanDepartment of Cancer Biology, Marvin and Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Temple Health, Philadelphia, PA, USA.
Wu-Min DengDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA, USA.
James G GrannemanDepartment of Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA.
Jeffrey HildesheimNational Cancer Institute, Bethesda, MD, USA.
Raghu KalluriDepartment of Cancer Biology, MD Anderson Cancer Center, Houston, TX, USA.
Ken S LauDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Ernst LengyelDepartment of Obstetrics and Gynecology, University of Chicago, Chicago, IL, USA.
Joakim LundebergSciLifeLab, Department of Gene Technology, KTH Royal Institute of Technology, Stockholm, Sweden.
Jorge MoscatWeill Cornell Medicine, Rockefeller University Campus, New York, NY, USA.
Peter S NelsonDepartment of Medicine, University of Washington, Seattle, WA, USA.
Kristian PietrasDepartment of Laboratory Medicine, Lund University, Lund, Sweden.
Katerina PolitiDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Ellen PuréDepartment of Biomedical Sciences, University of Pennsylvania, Philidelphia, PA, USA.
Ruth Scherz-ShouvalDepartment of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel.
Mara H ShermanDepartment of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, OR, USA.
David TuvesonCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Ashani T WeeraratnaSidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Richard M WhiteMemorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA.
Melissa H WongDepartment of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, OR, USA.
Elisa C WoodhouseNational Cancer Institute, Bethesda, MD, USA.
Ying ZhengDepartment of Bioengineering, University of Washington, Seattle, WA, USA.
Simon W HaywardDepartment of Surgery, NorthShore University HealthSystem, Evanston, IL, USA.
Sheila A StewartDepartment of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, MO, USA.
National Cancer Institute · USNorthShore University HealthSystem · USOregon Health & Science University · USUniversity of Washington · USWashington University in St. Louis · USCedars-Sinai Medical Center · USCold Spring Harbor Laboratory · USCornell University · USFox Chase Cancer Center · USLund University · SERockefeller University · USScience for Life Laboratory · SESidney Kimmel Cancer Center · USStanford University · USThe University of Texas MD Anderson Cancer Center · USTulane University · USUniversity of Chicago · USUniversity of Pennsylvania · USUniversity of Wisconsin–Madison · USVanderbilt University · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MTumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MProject 3 - Immune analysis of clinical trial samplesP01CA217805 · NCI · UNIVERSITY OF PENNSYLVANIA · PI HAAS, ANDREW R · 2018 to 2022
$10.4MAnalysis of Cellular Plasticity in White Adipose Tissue.R01DK062292 · NIDDK · WAYNE STATE UNIVERSITY · PI James G Granneman · 2003 to 2026
$7.6MTuft cell heterogeneity in function, lineage, and structure in ileal inflammatory diseaseR01DK103831 · NIDDK · VANDERBILT UNIVERSITY · PI LAU, KEN S · 2016 to 2024
$4.4MUncovering the Biology of Resistance to Tyrosine Kinase Inhibitors in EGFR Mutant Lung Cancer Patient-Derived Models.U01CA235747 · NCI · YALE UNIVERSITY · PI NGUYEN, DON X, POLITI, KATERINA ABIGAIL · 2019 to 2023
$3.9MTissue Microenvironment ant Tumor Hotspots in DrosophilaR01CA227789 · NCI · TULANE UNIVERSITY OF LOUISIANA · PI DENG, WU-MIN · 2019 to 2023
$1.7MMechanistic investigation of malignant rhabdoid childhood tumor using the Drosophila modelR01CA224381 · NCI · TULANE UNIVERSITY OF LOUISIANA · PI DENG, WU-MIN · 2018 to 2022
$1.7MNCATS NIH HHS UL1 TR001863NCI NIH HHS P01 CA217805NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA010815NCI NIH HHS R01 CA224381NCI NIH HHS R01 CA227789NCI NIH HHS U01 CA235747NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK062292NIDDK NIH HHS R01 DK103831
Abstract
Significant advances have been made towards understanding the role of immune cell-tumor interplay in either suppressing or promoting tumor growth, progression, and recurrence, however, the roles of additional stromal elements, cell types and/or cell states remain ill-defined. The overarching goal of this NCI-sponsored workshop was to highlight and integrate the critical functions of non-immune stromal components in regulating tumor heterogeneity and its impact on tumor initiation, progression, and resistance to therapy. The workshop explored the opposing roles of tumor supportive
Indexed as
cellular plasticityextracellular matrixstromal heterogeneitytherapy resistancetumor microenvironment
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.