ArticleResearch in pharmaceutical sciences2020
Discovery of novel isatin-based thiosemicarbazones: synthesis, antibacterial, antifungal, and antimycobacterial screening.
Article in Research in pharmaceutical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Characterization of six bioactive compounds from two soil-derivedResearch in pharmaceutical sciences · 2025Article
- Multicomponent reaction for synthesis, molecular docking, and anti-inflammatory evaluation of novel indole-thiazole hybrid derivatives.Molecular diversity · 2025Article
- Synthesis of thiosemicarbazone derivatives and evaluation of their cytotoxicity with emphasis on ferroptosis biomarkers; anResearch in pharmaceutical sciences · 2025Article
- Antifungal effects of thiosemicarbazone-chalcones on Aspergillus, Candida and Sporothrix strains.Archives of microbiology · 2025Article
- Design, synthesis, in vitro, and in silico studies of 4-fluorocinnamaldehyde based thiosemicarbazones as urease inhibitors.Scientific reports · 2025Article
- Design, synthesis, QSAR modelling and molecular dynamic simulations of N-tosyl-indole hybrid thiosemicarbazones as competitive tyrosinase inhibitors.Scientific reports · 2024Article
- An Insight into Fluorinated Imines and Hydrazones as Antibacterial Agents.International journal of molecular sciences · 2024Review
- Exploration of morpholine-thiophene hybrid thiosemicarbazones for the treatment of ureolytic bacterial infections via targeting urease enzyme: Synthesis, biochemical screening and computational analysis.Frontiers in chemistry · 2024Article
- Tripeptides conjugated with thiosemicarbazones: new inhibitors of tyrosinase for cosmeceutical use.Journal of enzyme inhibition and medicinal chemistry · 2023Article
- 5-Methoxyisatin N(4)-Pyrrolidinyl Thiosemicarbazone (MeOIstPyrd) Restores Mutant p53 and Inhibits the Growth of Skin Cancer Cells, In Vitro.ACS omega · 2023Article
- QSAR Studies, Molecular Docking, Molecular Dynamics, Synthesis, and Biological Evaluation of Novel Quinolinone-Based Thiosemicarbazones againstAntibiotics (Basel, Switzerland) · 2022Article
- Novel N-substituted indole hydrazones as potential antiplatelet agents: synthesis, biological evaluations, and molecular docking studies.Research in pharmaceutical sciences · 2022Article
- 5-Aryl-1-Arylideneamino-1Molecules (Basel, Switzerland) · 2021Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
background and purposeA group of thiosemicarbazones were prepared and their structures were confirmed by spectroscopic methods such as IR and H-NMR, mass spectrometry and also analytical method like elemental analysis. The synthesized semicarbazones were then assessed for their inhibitory activity against bacterial strains including EXPERIMENTAL APPROACH: The schiff bases of isatin ( FINDINGS /
resultsThe results disclosed that all compounds have noticeable inhibitory activity. Compounds CONCLUSION AND IMPLICATIONS: To sum up, amongst the 10 synthesized compounds, fluorinated derivatives exhibited remarkable activities against both gram negative strains and candida albicans microorganism. Therefore, they should be considered as a clue for further modifications in next investigations. Furthermore, inserting a small/medium size halogen atom with electron-withdrawing and lipophilic properties increases anti- salmonella activity of these compounds and moreover 2-halogenated semithiocarbazones presented promising antimycobacterial activity.
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