Evidence map›Paper›PMID 33088278›Full record

ArticleFrontiers in psychiatry2020

Ketamine Administration Leads to Learning-Memory Dysfunction and Decreases Serum Brain-Derived Neurotrophic Factor in Rats.

Miao Li, Aiming Xie, Ya Liu, Qian Zeng, Shucai Huang, Qiuping Huang, Tianli Shao, Xinxin Chen, Zhenjiang Liao, Yi Cai and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Miao LiDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, and National Clinical Research Center for Mental Disorders, Changsha, China.
Aiming XieAffiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science & Technology, Wuhan, China.
Ya LiuDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, China.
Qian ZengDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, China.
Shucai HuangDepartment of Psychiatry, The Fourth People's Hospital of Wuhu, Wuhu, China.
Qiuping HuangDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, and National Clinical Research Center for Mental Disorders, Changsha, China.
Tianli ShaoDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, and National Clinical Research Center for Mental Disorders, Changsha, China.
Xinxin ChenDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, and National Clinical Research Center for Mental Disorders, Changsha, China.
Zhenjiang LiaoDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, and National Clinical Research Center for Mental Disorders, Changsha, China.
Yi CaiDepartment of Psychiatry, Geriatric and Somatic Diseases, Brain Hospital of Human Province, Hunan University of Chinese Medicine Clinical College, Hunan Mental Behavior Disorder Research Center, Changsha, China.
Zhijie XiaoDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, China.
Xiaojie ZhangDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, and National Clinical Research Center for Mental Disorders, Changsha, China.
Hongxian ShenDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, and National Clinical Research Center for Mental Disorders, Changsha, China.
Second Xiangya Hospital of Central South University · CNHunan Institute of Mental Health · CNCentral South University · CNChangsha Central Hospital · CNHuazhong University of Science and Technology · CNHunan University · CNThe Fourth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study investigated the effects of acute or chronic ketamine administration on learning and memory function as well as levels of brain-derived neurotrophic factor (BDNF) in the hippocampus and blood in order to explore the potential correlation between learning-memory dysfunction and ketamine.

methodsRats were treated with 25 mg/kg ketamine for 3 d (n = 20) or 14 d (n = 20). Saline-treated rats were used as controls. The Morris water maze test was used to evaluate spatial learning and memory after 10 d of withdrawal. The level of BDNF in serum and the hippocampus were measured by ELISA.

resultsThe number of platform crossings and residence time in the target platform quadrant were significantly reduced in ketamine 3 d and 14 d groups than in the saline controls (both

conclusionChronic ketamine exposure (25 mg/kg) causes spatial learning and memory deficits in SD rats, which may be associated with decreased serum BDNF levels.

Indexed as

brain-derived neurotrophic factorketamine administrationmemoryMorris water mazespatial learning

Identifiers

PMID33088278
PMCPMC7544893
OpenAlexW3088550254

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.