ArticleWorld journal of gastroenterology2020
Risk prediction rule for advanced neoplasia on screening colonoscopy for average-risk individuals.
Article in World journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Establishment of clinical predictive model based on the study of influence factors in patients with colorectal polyps.Frontiers in surgery · 2023Article
- A scoping review of risk-stratified bowel screening: current evidence, future directions.Cancer causes & control : CCC · 2022Article
- Risk factors and prediction algorithm for advanced neoplasia on screening colonoscopy for average-risk individuals.Therapeutic advances in gastroenterology · 2022Article
- The Natural History of Colonic Diverticulosis: Much Ado about Nothing?Inflammatory intestinal diseases · 2018Review
- The Natural History of Incidental Colonic Diverticulosis on Screening Colonoscopy.Canadian journal of gastroenterology & hepatology · 2018Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn resource-limited countries, risk stratification can be used to optimize colorectal cancer screening. Few prospective risk prediction models exist for advanced neoplasia (AN) in true average-risk individuals.
aimTo create and internally validate a risk prediction model for detection of AN in average-risk individuals.
methodsProspective study of asymptomatic individuals undergoing first screening colonoscopy. Detailed characteristics including diet, exercise and medications were collected. Multivariate logistic regression was used to elucidate risk factors for AN (adenoma ≥1 cm, villous histology, high-grade dysplasia or carcinoma). The model was validated through bootstrapping, and discrimination and calibration of the model were assessed.
results980 consecutive individuals (51% F; 49% M) were enrolled. Adenoma and AN detection rates were 36.6% (F 29%: M 45%;
conclusionThe prevalence of adenoma and AN in average-risk Lebanese individuals is similar to the West. Age, smoking, and BMI are important predictors of AN, with obesity being particularly powerful. Though external validation is needed, this model provides an important platform for improved risk-stratification for screening programs in regions where universal screening is not currently employed.
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