Evidence map›Paper›PMID 33087943›Full record

ArticleElectrochimica acta2020

Electrochemical Reduction and Oxidation of Eight Unnatural 2'-Deoxynucleosides at a Pyrolytic Graphite Electrode.

Jan Špaček, Nilesh Karalkar, Miroslav Fojta, Joseph Wang, Steven A Benner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Electrochimica acta, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jan ŠpačekDepartment of Biophysical Chemistry and Molecular Oncology Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 65 Brno, The Czech Republic.
Nilesh KaralkarFoundation for Applied Molecular Evolution, 13709 Progress Blvd., Alachua, FL 32615, USA.
Miroslav FojtaDepartment of Biophysical Chemistry and Molecular Oncology Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 65 Brno, The Czech Republic.
Joseph WangDepartment of NanoEngineering, University of California San Diego, La Jolla, CA 92093, USA.
Steven A BennerFoundation for Applied Molecular Evolution, 13709 Progress Blvd., Alachua, FL 32615, USA.

Funding

Transforming Life Sciences: Artificial LifeR01GM128186 · NIGMS · FOUNDATION FOR APPLIED MOLECULAR EVOLUTN · PI BENNER, STEVEN A · 2017 to 2021
$3.4M
NIGMS NIH HHS R01 GM128186
6 · The paper itself

Abstract

Recently we showed the reduction and oxidation of six natural 2'-deoxynucleosides in the presence of the ambient oxygen using the very broad potential window of a pyrolytic graphite electrode (PGE). Using the same procedure, 2'-deoxynucleoside analogs (dNs) that are parts of an artificially expanded genetic information system (AEGIS) were analyzed. Seven of the eight tested AEGIS dNs provided specific signals (voltammetric redox peaks). These signals, described here for the first time, will be used in future work to analyze DNA built from expanded genetic alphabets, helping to further develop AEGIS technology and its applications. Comparison of the electrochemical behavior of unnatural dNs with the previously documented behaviors of natural dNs also provides insights into the mechanisms of their respective redox processes.

Indexed as

electrochemical oxidationelectrochemical reductionelectrochemistrypyrolytic graphiteunnatural DNA

Identifiers

PMID33087943
PMCPMC7571600

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.