Evidence map›Paper›PMID 33087905›Full record

ArticleNature methods2020

Next-generation GRAB sensors for monitoring dopaminergic activity in vivo.

Fangmiao Sun, Jingheng Zhou, Bing Dai, Tongrui Qian, Jianzhi Zeng, Xuelin Li, Yizhou Zhuo, Yajun Zhang, Yipan Wang, Cheng Qian and 6 more

Open access · greenAbstract read
In one paragraph

Article in Nature methods, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 309 papers.

0numbers the graph read from it
0cells of the map it votes in
309citing papers in PubMed
22.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

309 citing papers in PubMed, 505 citations in OpenAlex.

  1. Article
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  3. Effort, timing and choice: a refined rodent effort choice task with excellent sensitivity to dopamine modulators.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  7. Impact of ΔThe Journal of pharmacology and experimental therapeutics · 2026
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  14. The Synaptic Vesicle Priming Protein Munc13 Mediates Evoked Somatodendritic Dopamine Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  15. Article
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249 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Fangmiao Sun *State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Jingheng Zhou *Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0003-0280-6166
Bing Dai *Neuroscience Institute, Department of Psychiatry, New York University School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-4217-0369
Tongrui QianState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Jianzhi ZengState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-5380-6281
Xuelin LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Yizhou ZhuoState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Yajun ZhangState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Yipan WangState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Cheng QianState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Ke TanState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Jiesi FengState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Hui DongState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Dayu LinNeuroscience Institute, Department of Psychiatry, New York University School of Medicine, New York, NY, USA. Dayu.Lin@nyulangone.org.ORCID http://orcid.org/0000-0003-2006-0791
Guohong CuiNeurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA. cuig@mail.nih.gov.ORCID http://orcid.org/0000-0002-4555-028X
Yulong LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China. yulongli@pku.edu.cn.ORCID http://orcid.org/0000-0002-9166-9919
Peking University · CNNational Institutes of Health · USNew York University · USMcGovern Institute for Brain Research · US

Funding

Basal Ganglia in Health and DiseaseZIAES103310 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CUI, GUOHONG · 2016 to 2025
$23.6M
Research Supplement to Promote Diversity in Health-Related ResearchR01MH101377 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Dayu Lin · 2013 to 2026
$8.6M
Novel fluorescent sensors based on GPCRs for imaging neuromodulationU01NS103558 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIRES, SAMUEL ANDREW, LI, YULONG · 2017 to 2019
$2.2M
Investigating the neural mechanism of maternal motivationR21HD090563 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LIN, DAYU · 2018 to 2019
$466k
Intramural NIH HHS ZIA ES103310NICHD NIH HHS R21 HD090563NIMH NIH HHS R01 MH101377NINDS NIH HHS U01 NS103558
6 · The paper itself

Abstract

Dopamine (DA) plays a critical role in the brain, and the ability to directly measure dopaminergic activity is essential for understanding its physiological functions. We therefore developed red fluorescent G-protein-coupled receptor-activation-based DA (GRAB

Indexed as

AnimalsBiosensing TechniquesBrainDopamineDrosophilaGreen Fluorescent ProteinsHEK293 CellsHumansLuminescent ProteinsMiceNeuronsRatsReceptors, DopamineReceptors, G-Protein-CoupledRed Fluorescent ProteinSexual BehaviorDopamineenhanced green fluorescent proteinGreen Fluorescent ProteinsLuminescent ProteinsReceptors, DopamineReceptors, G-Protein-CoupledRed Fluorescent Protein

Identifiers

PMID33087905
PMCPMC7648260
OpenAlexW3093645876

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.