ArticleEye (London, England)2021
Myopia-related stepwise and quadrant retinal microvascular alteration and its correlation with axial length.
Article in Eye (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Effect of caffeine on superficial retinal vasculature of the macula in high myopes using optical coherence tomography angiography - A pilot study.Journal of optometryTrial
- Long-term optic nerve head microvascular impairment after acute primary angle closure: an OCTA study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Retinal single-cell blood velocity in eyes with varied axial length using adaptive optics scanning laser ophthalmoscopy.Eye (London, England) · 2026Article
- Artificial intelligence assisted quantitative analysis of fundus structural and vascular alterations reveals fundus tessellation as a robust biomarker of myopia severity.Frontiers in cell and developmental biology · 2026Article
- Alterations in Macular and Peripapillary Vessel Density Following Implantable Collamer Lens Surgery in Highly Myopic Eyes and Their Potential Association with 2-Year Axial Length Changes.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Characteristics of Retinal Oxygen Kinetics and Blood Flow in Myopia of Different Degrees.Investigative ophthalmology & visual science · 2025Article
- Quadrant asymmetry alteration of deep retinal capillary plexus degeneration in pathological myopia.Journal of translational medicine · 2025Article
- The Significance of OCTA in Studying Vessel Density and Retinal Thickness in Individuals with Myopia.Medicina (Kaunas, Lithuania) · 2025Article
- Retinal vessel density alteration after FS-LASIK for myopia with different axial lengths.International journal of ophthalmology · 2025Article
- Binocular visual performance and optical quality of trifocal intraocular lens in Chinese patients with high myopic cataract.PloS one · 2025Article
- Investigation of choroidal vascular alterations in eyes with myopia using ultrawidefield optical coherence tomography angiography.BMJ open ophthalmology · 2024Article
- Peripheral Superficial Retina Vascular Density and Area of Radial Peripapillary Capillaries Changes in Myopic Individuals: A Wide-Field OCT Angiography Study.Translational vision science & technology · 2024Article
- Exome-wide association study identifies KDELR3 mutations in extreme myopia.Nature communications · 2024Article
- Inner Retinal Microvasculature With Refraction in Juvenile Rhesus Monkeys.Translational vision science & technology · 2024Article
- Peripheral Ganglion Cell Complex Thickness and Retinal Microvasculature in Myopia Using Wide-Field Swept-Source OCT.Translational vision science & technology · 2024Article
- Observation of structural and vascular features of retina and choroid in myopia using ultra-widefield SS-OCTA.BMC ophthalmology · 2024Article
- Relationship between the structure and microcirculation of the optic disc region and myopic traction maculopathy in highly myopic eyes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- A wireless battery-free eye modulation patch for high myopia therapy.Nature communications · 2024Article
- Reduced contrast sensitivity function is correlated with changes to cone photoreceptors in simple high myopia.Frontiers in neuroscience · 2024Article
- Retinal and Choroidal Changes Following Implantable Collamer Lens V4c Implantation in High Myopia Patients-A 1-Year Follow-Up Study.Diagnostics (Basel, Switzerland) · 2023Article
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Authors and funding
6 authors.
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Abstract
purposeTo investigate the characteristics of retinal vascular alterations in patients with varying degrees of myopia, and to determine correlated variables and alteration patterns over different retinal zones.
methodsA total of 208 right eyes of 208 patients with myopia were enrolled and divided into mild, moderate, high, and extreme myopia groups. The macular vasculature in superficial, deep, and whole retinal layers was imaged with optical coherence tomography angiography (OCTA). The vessel densities over the whole annular zone, four quadrants, and six annuli were quantified as fractal dimension using a customized software. Simple linear regressions and ridge regression were used to determine and compare explanatory variables of microvascular density.
resultsThe microvascular density within the superficial, deep and whole retinal layers was highest in mild myopia group, second highest in moderate myopia group, second lowest in high myopia group and lowest in extreme myopia group. Within the same layer, differences between any two groups were significant (all p < 0.05). Among the four quadrants, only the inferior nasal (IN) quadrant showed no difference in microvascular density between mild and moderate groups. Ridge regression indicated that microvascular density values in all three layers were more strongly correlated with axial length (AL) (scaled estimates -0.139, -0.103, -0.154; all p < 0.001) than with spherical equivalent (SE) (scaled estimates -0.052, -0.096, -0.057; all p < 0.05).
conclusionsWe characterized a stepwise and quadrant alteration of retinal microvascular density from mild to extreme myopia, which was more strongly affected by axial elongation, although both AL and SE were meaningful indicators.
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