ArticleScientific reports2020
Multi-strain volatile profiling of pathogenic and commensal cutaneous bacteria.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Volatilomic Profiling of Early-Stage Biotransformation Enables Identification of Diagnostic Volatiles inFoods (Basel, Switzerland) · 2026Article
- Design of solid phase microextraction patches for the detection of volatile metabolites associated with Burkholderia cepacia.Applied microbiology and biotechnology · 2026Article
- Data-driven exploration of electronic nose technology to differentiate bacteria in blood cultures under biofilm-promoting conditions.Scientific reports · 2026Article
- Untargeted GC-IMS Metabolomics of Wound Headspace for Bacterial Infection Biomarker Discovery.Metabolites · 2026Article
- Bacterial species differentiation via real-time detection of microbial volatile organic compounds using a wavelength multiplexed photoionization detector and AI image-based analysis.Scientific reports · 2026Article
- Skin-derived volatile organic compounds trigger redox signalling pathways in human keratinocytesRSC advances · 2025Article
- Profiling of Volatile Metabolites ofInternational journal of molecular sciences · 2025Article
- Volatile organic compound detection of Buruli ulcer disease: Headspace analysis of Mycobacterium ulcerans and used gauzes of Buruli-compatible ulcers.PLoS neglected tropical diseases · 2024Article
- Identification of volatile metabolites produced from levodopa metabolism by different bacteria strains of the gut microbiome.BMC microbiology · 2024Article
- The Potential of Fecal Volatile Organic Compound Analysis for the Early Diagnosis of Late-Onset Sepsis in Preterm Infants: A Narrative Review.Sensors (Basel, Switzerland) · 2024Review
- Modern approaches for detection of volatile organic compounds in metabolic studies focusing on pathogenic bacteria: Current state of the art.Journal of pharmaceutical analysis · 2024Review
- Predicting Chronological Age via the Skin Volatile Profile.Journal of the American Society for Mass Spectrometry · 2024Article
- Metabolic profiling of bacteria with the application of polypyrrole-MOF SPME fibers and plasmonic nanostructured LDI-MS substrates.Scientific reports · 2024Article
- Volatilomes of human infection.Analytical and bioanalytical chemistry · 2024Review
- Article
- Human scent guides mosquito thermotaxis and host selection under naturalistic conditions.Current biology : CB · 2023Article
- Microbial Volatiles as Diagnostic Biomarkers of Bacterial Lung Infection in Mechanically Ventilated Patients.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Current Limitations of Staph Infection Diagnostics, and the Role for VOCs in Achieving Culture-Independent Detection.Pathogens (Basel, Switzerland) · 2023Review
- Screening and Characterization ofAntioxidants (Basel, Switzerland) · 2023Article
- Rapid Identification of Carbapenemase-ProducingInfection and drug resistance · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The detection of volatile organic compounds (VOC) emitted by pathogenic bacteria has been proposed as a potential non-invasive approach for characterising various infectious diseases as well as wound infections. Studying microbial VOC profiles in vitro allows the mechanisms governing VOC production and the cellular origin of VOCs to be deduced. However, inter-study comparisons of microbial VOC data remains a challenge due to the variation in instrumental and growth parameters across studies. In this work, multiple strains of pathogenic and commensal cutaneous bacteria were analysed using headspace solid phase micro-extraction coupled with gas chromatography-mass spectrometry. A kinetic study was also carried out to assess the relationship between bacterial VOC profiles and the growth phase of cells. Comprehensive bacterial VOC profiles were successfully discriminated at the species-level, while strain-level variation was only observed in specific species and to a small degree. Temporal emission kinetics showed that the emission of particular compound groups were proportional to the respective growth phase for individual S. aureus and P. aeruginosa samples. Standardised experimental workflows are needed to improve comparability across studies and ultimately elevate the field of microbial VOC profiling. Our results build on and support previous literature and demonstrate that comprehensive discriminative results can be achieved using simple experimental and data analysis workflows.
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