Evidence map›Paper›PMID 33087740›Full record

ArticleScientific reports2020

Electrophysiological correlates of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism.

Nikita Roy, Robert J Barry, Francesca E Fernandez, Chai K Lim, Mahmoud A Al-Dabbas, Diana Karamacoska, Samantha J Broyd, Nadia Solowij, Christine L Chiu, Genevieve Z Steiner

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  10. Genetic polymorphisms iniScience · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Nikita RoyNICM Health Research Institute and Translational Health Research Institute (THRI), Western Sydney University, Locked Bag 1797, Penrith, NSW, 2751, Australia.
Robert J BarryBrain & Behaviour Research Institute and School of Psychology, University of Wollongong, Wollongong, NSW, 2522, Australia.
Francesca E FernandezSchool of Health and Behavioural Science, Faculty of Health Sciences, Australian Catholic University, Brisbane, NSW, 4014, Australia.
Chai K LimFaculty of Medicine, Health and Human Sciences, Macquarie University, Macquarie Park, NSW, 2190, Australia.
Mahmoud A Al-DabbasNICM Health Research Institute and Translational Health Research Institute (THRI), Western Sydney University, Locked Bag 1797, Penrith, NSW, 2751, Australia.
Diana KaramacoskaNICM Health Research Institute and Translational Health Research Institute (THRI), Western Sydney University, Locked Bag 1797, Penrith, NSW, 2751, Australia.
Samantha J BroydSchool of Psychology and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, 2522, Australia.
Nadia SolowijSchool of Psychology and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, 2522, Australia.
Christine L ChiuFaculty of Medicine, Health and Human Sciences, Macquarie University, Macquarie Park, NSW, 2190, Australia.
Genevieve Z SteinerNICM Health Research Institute and Translational Health Research Institute (THRI), Western Sydney University, Locked Bag 1797, Penrith, NSW, 2751, Australia. G.Steiner@westernsydney.edu.au.
Illawarra Health and Medical Research Institute · AUTranslational Research Institute · AUMacquarie University · AUUniversity of Wollongong · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The brain-derived neurotrophic factor (BDNF) protein is essential for neuronal development. Val66Met (rs6265) is a functional polymorphism at codon 66 of the BDNF gene that affects neuroplasticity and has been associated with cognition, brain structure and function. The aim of this study was to clarify the relationship between BDNF Val66Met polymorphism and neuronal oscillatory activity, using the electroencephalogram (EEG), in a normative cohort. Neurotypical (N = 92) young adults were genotyped for the BDNF Val66Met polymorphism and had eyes open resting-state EEG recorded for four minutes. Focal increases in right fronto-parietal delta, and decreases in alpha-1 and right hemispheric alpha-2 amplitudes were observed for the Met/Met genotype group compared to Val/Val and Val/Met groups. Stronger frontal topographies were demonstrated for beta-1 and beta-2 in the Val/Met group versus the Val/Val group. Findings highlight BDNF Val66Met genotypic differences in EEG spectral amplitudes, with increased cortical excitability implications for Met allele carriers.

Indexed as

ElectroencephalographyPolymorphism, GeneticAdolescentAdultAllelesBrainBrain-Derived Neurotrophic FactorCodonCognitionCohort StudiesFemaleGenotypeHeterozygoteHumansMaleNeuronal PlasticityBDNF protein, humanBrain-Derived Neurotrophic FactorCodon

Identifiers

PMID33087740
PMCPMC7578797
OpenAlexW3093648136

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.