Evidence map›Paper›PMID 33087673›Full record

ArticleInternal medicine (Tokyo, Japan)2021

IgG4-related Sclerosing Cholangitis Complicated with Cholangiocarcinoma and Detected by Forkhead Box P3 Immunohistochemical Staining.

Tadashi Toyohara, Takahiro Nakazawa, Kais Zakharia, Shuya Shimizu, Katsuyuki Miyabe, Kenichi Harada, Kenji Notohara, Tomohiro Yamada, Katsumi Hayashi, Itaru Naitoh and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tadashi ToyoharaDepartment of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan.
Takahiro NakazawaDepartment of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan.
Kais ZakhariaDivision of Gastroenterology and Hepatology, University of Iowa, USA.
Shuya ShimizuDepartment of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan.
Katsuyuki MiyabeDepartment of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan.
Kenichi HaradaDepartment of Human Pathology, Kanazawa University School of Medicine, Japan.
Kenji NotoharaDepartment of Anatomic Pathology, Kurashiki Central Hospital, Japan.
Tomohiro YamadaDepartment of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan.
Katsumi HayashiDepartment of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan.
Itaru NaitohDepartment of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan.
Kazuki HayashiDepartment of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan.
Hiromi KataokaDepartment of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An 80-year-old man was admitted due to biliary stricture with autoimmune pancreatitis. Although radiographical examinations suggested Immunoglobulin G4-related sclerosing cholangitis (IgG4-SC), punched biopsies from the bile duct revealed adenocarcinoma. In the resected specimen, abundant N-terminus of Forkhead box P3 (Foxp3)-positive cells were localized in cholangiocarcinoma (CCA) tissue, while IgG4-positive cells were spread around the entire bile duct. Therefore, the case was diagnosed with IgG4-SC accompanied by CCA, not sporadic CCA. We herein report an informative case wherein IgG4-positive cells were abundant in CCA tissue and Foxp3 immunohistochemical staining allowed us to determine that this case had two entities.

Indexed as

Autoimmune DiseasesBile Duct NeoplasmsCholangiocarcinomaCholangitis, SclerosingAged, 80 and overBile Ducts, IntrahepaticDiagnosis, DifferentialHumansImmunoglobulin GMaleStaining and LabelingImmunoglobulin Gautoimmune pancreatitischolangiocarcinomaforkhead box P3immunoglobulin G4-related diseaseimmunoglobulin G4-related sclerosing cholangitis

Identifiers

PMID33087673
PMCPMC8024973

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.