Evidence map›Paper›PMID 33087586›Full record

ArticleAging2020

Polymerase I and transcript release factor transgenic mice show impaired function of hematopoietic stem cells.

Lin Bai, Ying Lyu, Guiying Shi, Keya Li, Yiying Huang, Yuanwu Ma, Yu-Sheng Cong, Lianfeng Zhang, Chuan Qin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Caveolin1: its roles in normal and cancer stem cells.Journal of cancer research and clinical oncology · 2021
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Lin BaiNHC Key Laboratory of Human Disease Comparative Medicine, The Institute of Laboratory Animal Sciences, CAMS&PUMC, Beijing 100021, China.
Ying LyuNHC Key Laboratory of Human Disease Comparative Medicine, The Institute of Laboratory Animal Sciences, CAMS&PUMC, Beijing 100021, China.
Guiying ShiNHC Key Laboratory of Human Disease Comparative Medicine, The Institute of Laboratory Animal Sciences, CAMS&PUMC, Beijing 100021, China.
Keya LiNHC Key Laboratory of Human Disease Comparative Medicine, The Institute of Laboratory Animal Sciences, CAMS&PUMC, Beijing 100021, China.
Yiying HuangNHC Key Laboratory of Human Disease Comparative Medicine, The Institute of Laboratory Animal Sciences, CAMS&PUMC, Beijing 100021, China.
Yuanwu MaNHC Key Laboratory of Human Disease Comparative Medicine, The Institute of Laboratory Animal Sciences, CAMS&PUMC, Beijing 100021, China.
Yu-Sheng CongInstitute of Aging Research, Hangzhou Normal University School of Medicine, Hangzhou 310036, China.
Lianfeng ZhangNHC Key Laboratory of Human Disease Comparative Medicine, The Institute of Laboratory Animal Sciences, CAMS&PUMC, Beijing 100021, China.
Chuan QinNHC Key Laboratory of Human Disease Comparative Medicine, The Institute of Laboratory Animal Sciences, CAMS&PUMC, Beijing 100021, China.
Hangzhou Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The age-dependent decline in stem cell function plays a critical role in aging, although the molecular mechanisms remain unclear. PTRF/Cavin-1 is an essential component in the biogenesis and function of caveolae, which regulates cell proliferation, endocytosis, signal transduction and senescence. This study aimed to analyze the role of PTRF in hematopoietic stem cells (HSCs) senescence using PTRF transgenic mice. Flow cytometry was used to detect the frequency of immune cells and hematopoietic stem/progenitor cells (HSCs and HPCs). The results showed than the HSC compartment was significantly expanded in the bone marrow of PTRF transgenic mice compared to age-matched wild-type (WT) mice, and exhibited the senescent phenotype characterized by G1 cell cycle arrest, increased SA-β-Gal activity and high levels of reactive oxygen species (ROS). The PTRF-overexpressing HSCs also showed significantly lower self-renewal and ability to reconstitute hematopoiesis

Indexed as

Cell ProliferationCellular SenescenceAnimalsCaveolin 1Cells, CulturedCell Self RenewalCyclin-Dependent Kinase Inhibitor p16G1 Phase Cell Cycle CheckpointsHematopoiesisHematopoietic Stem CellsMembrane ProteinsMice, Inbred C57BLMice, Transgenicp38 Mitogen-Activated Protein KinasesPhenotypeReactive Oxygen SpeciesCav1 protein, mouseCaveolin 1Cavin1 protein, mouseCdkn2a protein, mouseCyclin-Dependent Kinase Inhibitor p16Membrane Proteinsp38 Mitogen-Activated Protein KinasesReactive Oxygen SpeciesRNA-Binding Proteinscaveolin-1HSCsPTRF

Identifiers

PMID33087586
PMCPMC7655181
OpenAlexW3094055566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.