ArticleProceedings of the National Academy of Sciences of the United States of America2020
Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 2 pooled it
7.5field-weighted citation impact, top 2% of its field
What it found
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Who cites it
87 citing papers in PubMed, 2 syntheses or guidelines pooled it, 135 citations in OpenAlex.
- Global pattern and evolution of PPARγ in breast cancer: a 25-Year bibliometric and visualized knowledge map analysis.Frontiers in oncology · 2026Pooled it
- NR4A Family Genes: A Review of Comprehensive Prognostic and Gene Expression Profile Analysis in Breast Cancer.Frontiers in oncology · 2022Pooled it
- THBS2: the key hub linking breast cancer stroma, immunity, and therapeutic response.Clinical & experimental metastasis · 2026Review
- TRIM Protein Superfamily in Breast Cancer: Yin and Yang.Biochemical genetics · 2026Review
- Article
- Nur77 agonism invigorates Natural Killer cell immunity against hepatocellular carcinoma.Nature communications · 2026Article
- SAMHD1 promotes cardiac repair post myocardial infarction by targeting NR4a1 to regulate macrophage metabolic reprogramming.Journal of advanced research · 2026Article
- Narcissoside attenuates atherosclerosis by suppressing CD36-mediated foam cell formation via upregulation of NR4A1.Chinese medicine · 2026Article
- The Sirt2-Nur77 axis regulates muscle stem cell quiescence and senescence via epigenetic-metabolic synergy.Cell death & disease · 2026Article
- P2X7R deficiency alleviates cardiac senescence by enhancing mitophagy via the HuR/TRIM26/NR4A1 axis.Clinical and translational medicine · 2026Article
- miR-27b-3p directly targets PPARG to regulate pancreatic cancer progression.Discover oncology · 2026Article
- An epithelial-mesenchymal transition-related gene signature predicts prognosis, immune infiltration, and drug sensitivity in colorectal cancer.Cancer drug resistance (Alhambra, Calif.) · 2026Article
- Lipid Metabolic Reprogramming in Breast Cancer: Mechanisms and Emerging Therapeutic Strategies.Breast cancer (Dove Medical Press) · 2026Review
- Targeting OxLDL-mediated CD36 + CAF reprogramming potentiates PD-1 immunotherapy in osteosarcoma.Molecular cancer · 2025Article
- Disruption of heme homeostasis by nuclear receptor Nur77 induces pyroptosis through granzyme B-dependent GSDMC cleavage.Signal transduction and targeted therapy · 2025Article
- FABP4 in lipid metabolism and the tumor microenvironment: mechanisms and therapeutic potential.Lipids in health and disease · 2025Review
- NR4A nuclear receptor expression in human macrophages mediates apoptosis and controls Mycobacterium tuberculosis growth.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Nuclear Receptor Subfamily 4 Group A Member 1 Exacerbates Cardiac Remodeling by Inhibiting Mitochondrial Function Through the Peroxisome Proliferator-Activated Receptor γ Coactivator-1α/Nuclear Respiratory Factor 1/Transcription Factor A Mitochondrial Axis.Journal of the American Heart Association · 2025Article
- Genomic Crosstalk Between Nuclear Receptors in Hormone-dependent Cancers.Endocrinology · 2025Review
- The Nuclear Receptor Nurr1 Modulates the Expression and Activity of PPARγ in Human Pro-Inflammatory Macrophages.Scandinavian journal of immunology · 2025Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 1 institution in 1 country.
Peng-Bo YangState Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, 361005 Xiamen, Fujian Province, China.
Pei-Pei HouState Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, 361005 Xiamen, Fujian Province, China.ORCID 0000-0001-9912-2259
Fu-Yuan LiuState Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, 361005 Xiamen, Fujian Province, China.ORCID 0000-0001-7346-789X
Wen-Bin HongState Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, 361005 Xiamen, Fujian Province, China.ORCID 0000-0001-6002-5726
Hang-Zi ChenState Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, 361005 Xiamen, Fujian Province, China.
Xiao-Yu SunState Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, 361005 Xiamen, Fujian Province, China.
Peng LiState Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, 361005 Xiamen, Fujian Province, China.
Yi ZhangState Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, 361005 Xiamen, Fujian Province, China.
Cui-Yu JuState Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, 361005 Xiamen, Fujian Province, China.
Li-Juan LuoState Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, 361005 Xiamen, Fujian Province, China.
Sheng-Fu WuState Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, 361005 Xiamen, Fujian Province, China.
Jia-Xin ZhouState Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, 361005 Xiamen, Fujian Province, China.ORCID 0000-0002-7657-9923
Zhi-Jing WangState Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, 361005 Xiamen, Fujian Province, China.
Jian-Ping HeState Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, 361005 Xiamen, Fujian Province, China.
Li LiState Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, 361005 Xiamen, Fujian Province, China.
Tong-Jin ZhaoState Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, 361005 Xiamen, Fujian Province, China.
Xianming DengState Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, 361005 Xiamen, Fujian Province, China.ORCID 0000-0002-9354-5864
Tianwei LinState Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, 361005 Xiamen, Fujian Province, China twlin@xmu.edu.cn qiaow@xmu.edu.cn.ORCID 0000-0002-9293-4673
Qiao WuState Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, 361005 Xiamen, Fujian Province, China twlin@xmu.edu.cn qiaow@xmu.edu.cn.ORCID 0000-0002-2928-142X
Xiamen University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear receptor Nur77 participates in multiple metabolic regulations and plays paradoxical roles in tumorigeneses. Herein, we demonstrated that the knockout of Nur77 stimulated mammary tumor development in two mouse models, which would be reversed by a specific reexpression of Nur77 in mammary tissues. Mechanistically, Nur77 interacted and recruited corepressors, the SWI/SNF complex, to the promoters of
Indexed as
AdultAgedAged, 80 and overAnimalsBreastBreast NeoplasmsCell ProliferationDisease Models, AnimalDisease ProgressionDNA-Binding ProteinsFatty AcidsFemaleHumansKaplan-Meier EstimateLipid MetabolismMammary Glands, Animalcytosporone BDNA-Binding ProteinsFatty AcidsNR4A1 protein, humanNr4a1 protein, mouseNuclear Receptor Subfamily 4, Group A, Member 1PhenylacetatesPPAR gammaPPARG protein, humanPparg protein, mouseTRIM13 protein, humanTumor Suppressor Proteinsbreast cancercytosporone-Bfatty acid uptakenuclear receptors Nur77 and PPARγubiquitination
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.