ArticlemSphere2020
Humidity and Deposition Solution Play a Critical Role in Virus Inactivation by Heat Treatment of N95 Respirators.
Article in mSphere, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Disinfection methods against SARS-CoV-2: a systematic review.The Journal of hospital infection · 2022Pooled it
- An Overview of Diverse Strategies To InactivateEcoSal Plus · 2023Review
- Surface Inactivation of a SARS-CoV-2 Surrogate with Hypochlorous Acid is Impacted by Surface Type, Contact Time, Inoculum Matrix, and Concentration.Food and environmental virology · 2023Article
- How to Tackle Bacteriophages: The Review of Approaches with Mechanistic Insight.International journal of molecular sciences · 2023Review
- Safe use of PHI6 IN the experimental studies.Heliyon · 2023Article
- Article
- Virucidal N95 Respirator Face Masks via Ultrathin Surface-Grafted Quaternary Ammonium Polymer Coatings.ACS applied materials & interfaces · 2022Article
- Article
- Monitoring SARS-CoV-2 in sewage: Toward sentinels with analytical accuracy.The Science of the total environment · 2022Article
- Heat-Treated Virus Inactivation Rate Depends Strongly on Treatment Procedure: Illustration with SARS-CoV-2.Applied and environmental microbiology · 2021Article
- Heat-treated virus inactivation rate depends strongly on treatment procedure: illustration with SARS-CoV-2.bioRxiv : the preprint server for biology · 2021Article
- Heat and Humidity for Bioburden Reduction of N95 Filtering Facepiece Respirators.Applied biosafety : journal of the American Biological Safety Association · 2021Review
- Monitoring SARS-CoV-2 decontamination by dry heat and ultraviolet treatment with a swine coronavirus as a surrogate.Infection prevention in practice · 2021Article
- Validation of N95 Filtering Facepiece Respirator Decontamination Methods Available at a Large University Hospital.Open forum infectious diseases · 2021Article
- Decontamination and Reuse of N95 Filtering Facepiece Respirators: Where Do We Stand?Anesthesia and analgesia · 2021Review
- Applying heat and humidity using stove boiled water for decontamination of N95 respirators in low resource settings.PloS one · 2021Article
- The impact and implications of COVID-19: Reflections on the Zimbabwean society.Social sciences & humanities open · 2021Article
- Decontamination of N95 respirators against SARS-CoV-2: A scoping review.Journal of dentistry · 2021Article
- Viricidal Efficacy of a 405-nm Environmental Decontamination System for Inactivation of Bacteriophage Phi6: Surrogate for SARS-CoV-2.Photochemistry and photobiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
Supply shortages of N95 respirators during the coronavirus disease 2019 (COVID-19) pandemic have motivated institutions to develop feasible and effective N95 respirator reuse strategies. In particular, heat decontamination is a treatment method that scales well and can be implemented in settings with variable or limited resources. Prior studies using multiple inactivation methods, however, have often focused on a single virus under narrowly defined conditions, making it difficult to develop guiding principles for inactivating emerging or difficult-to-culture viruses. We systematically explored how temperature, humidity, and virus deposition solutions impact the inactivation of viruses deposited and dried on N95 respirator coupons. We exposed four virus surrogates across a range of structures and phylogenies, including two bacteriophages (MS2 and phi6), a mouse coronavirus (murine hepatitis virus [MHV]), and a recombinant human influenza A virus subtype H3N2 (IAV), to heat treatment for 30 min in multiple deposition solutions across several temperatures and relative humidities (RHs). We observed that elevated RH was essential for effective heat inactivation of all four viruses tested. For heat treatments between 72°C and 82°C, RHs greater than 50% resulted in a >6-log
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.