ArticleScience translational medicine2020
Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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23citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- The Nucleolus in Human Disease: Ribosome Biogenesis, Nucleolar Surveillance, and Therapeutic Opportunities.Biomolecules · 2026Review
- RPS19 and RPL5 haploinsufficient models reveal divergent ribosomal subunit controls of fetal hematopoiesis.Nature communications · 2026Article
- Advances in the characterization of in vitro-generated red blood cells: from biophysical properties to functional applications.Stem cell research & therapy · 2025Review
- RPS19 and RPL5 Haploinsufficient Models Reveal Divergent Ribosomal Subunit Controls of Fetal Hematopoiesis.Research square · 2025Article
- Machine learning-based proteomics profiling of ALS identifies downregulation of RPS29 that maintains protein homeostasis and STMN2 level.Communications biology · 2025Article
- Review
- Gene therapy for congenital marrow failure syndromes - no longer grasping at straws?Haematologica · 2023Article
- Sickle cell disease classification using deep learning.Heliyon · 2023Article
- Article
- Targeting of Calbindin 1 rescues erythropoiesis in a human model of Diamond Blackfan anemia.Blood cells, molecules & diseases · 2023Article
- Scd1 Deficiency in Early Embryos Affects Blastocyst ICM Formation through RPs-Mdm2-p53 Pathway.International journal of molecular sciences · 2023Article
- An RPS19-edited model for Diamond-Blackfan anemia reveals TP53-dependent impairment of hematopoietic stem cell activity.JCI insight · 2023Article
- Hematopoietic cell transplantation and gene therapy for Diamond-Blackfan anemia: state of the art and science.Frontiers in oncology · 2023Review
- The impact of TP53 activation and apoptosis in primary hereditary microcephaly.Frontiers in neuroscience · 2023Review
- Bioinformatics analysis based on crucial genes of endothelial cells in rheumatoid.Frontiers in genetics · 2023Article
- Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium.BMC biology · 2022Article
- Deficiency of ribosomal protein S26, which is mutated in a subset of patients with Diamond Blackfan anemia, impairs erythroid differentiation.Frontiers in genetics · 2022Article
- Variable Clinical Features in a Large Family With Diamond Blackfan Anemia Caused by a Pathogenic Missense Mutation inFrontiers in genetics · 2022Article
- Diamond-Blackfan anemia.Hematology. American Society of Hematology. Education Program · 2021Article
- Using the Zebrafish as a Genetic Model to Study Erythropoiesis.International journal of molecular sciences · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
23 authors at 6 institutions in 2 countries.
Alison M TaylorStem Cell Program, Boston Children's Hospital and Harvard Stem Cell Institute, Boston, MA 02115, USA.ORCID 0000-0001-9341-535X
Elizabeth R MacariStem Cell Program, Boston Children's Hospital and Harvard Stem Cell Institute, Boston, MA 02115, USA.
Iris T ChanStem Cell Program, Boston Children's Hospital and Harvard Stem Cell Institute, Boston, MA 02115, USA.ORCID 0000-0001-9555-8522
Megan C BlairStem Cell Program, Boston Children's Hospital and Harvard Stem Cell Institute, Boston, MA 02115, USA.
Sergei DoulatovStem Cell Program, Boston Children's Hospital and Harvard Stem Cell Institute, Boston, MA 02115, USA.ORCID 0000-0002-1328-364X
Linda T VoStem Cell Program, Boston Children's Hospital and Harvard Stem Cell Institute, Boston, MA 02115, USA.ORCID 0000-0002-7999-8760
David M RaiserDivision of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA.
Kavitha SivaStem Cell Center, Lund University, Lund 22184, Sweden.ORCID 0000-0001-9480-4496
Anindita BasakDivision of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA.ORCID 0000-0002-7046-4500
Mehdi PirouzStem Cell Program, Boston Children's Hospital and Harvard Stem Cell Institute, Boston, MA 02115, USA.ORCID 0000-0002-7439-6066
Arish N ShahMIT Department of Biology and David H. Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA.ORCID 0000-0002-4036-9772
Katherine McGrathStem Cell Program, Boston Children's Hospital and Harvard Stem Cell Institute, Boston, MA 02115, USA.ORCID 0000-0001-8201-0234
Jessica M HumphriesStem Cell Program, Boston Children's Hospital and Harvard Stem Cell Institute, Boston, MA 02115, USA.
Emma StillmanStem Cell Program, Boston Children's Hospital and Harvard Stem Cell Institute, Boston, MA 02115, USA.ORCID 0000-0002-2722-9492
Blanche P AlterClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20850, USA.ORCID 0000-0001-8458-7774
Eliezer CaloMIT Department of Biology and David H. Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA.ORCID 0000-0002-3006-2742
Richard I GregoryStem Cell Program, Boston Children's Hospital and Harvard Stem Cell Institute, Boston, MA 02115, USA.ORCID 0000-0001-8090-8673
Vijay G SankaranDivision of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA.ORCID 0000-0003-0044-443X
Johan FlygareStem Cell Center, Lund University, Lund 22184, Sweden.ORCID 0000-0002-1962-5276
Benjamin L EbertDivision of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA.ORCID 0000-0003-0197-5451
Yi ZhouStem Cell Program, Boston Children's Hospital and Harvard Stem Cell Institute, Boston, MA 02115, USA.ORCID 0000-0003-0935-1635
George Q DaleyStem Cell Program, Boston Children's Hospital and Harvard Stem Cell Institute, Boston, MA 02115, USA.ORCID 0000-0002-6346-5919
Leonard I ZonStem Cell Program, Boston Children's Hospital and Harvard Stem Cell Institute, Boston, MA 02115, USA. zon@enders.tch.harvard.edu.ORCID 0000-0003-0860-926X
Boston Children's Hospital · USBroad Institute · USLund University · SEMassachusetts Institute of Technology · USBrigham and Women's Hospital · USDepartment of Health and Human Services · US
Funding
TRANSCRIPTION FACTOR GATA-1 IN TERMINAL ERYTHROID DEVELOPMENTP01HL032262 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI YIEN, YVETTE Y · 1985 to 2021
$38.9MTranscriptional and epigenetic heterogeneity of stem/progenitor cellsP01HL131477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI DANIEL G TENEN · 2017 to 2026
$24.6MCustomized stem cells for clinical application in blood disordersR24DK092760 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI COLLINS, JAMES J, DALEY, GEORGE Q · 2011 to 2018
$10.7MHuman Pluripotent Stem Cell and Progenitor Models of Cardiac and Blood DiseasesU01HL100001 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI DALEY, GEORGE Q, ORKIN, STUART H · 2009 to 2015
$8.9MStem cells for therapeutics discovery in genetic blood disordersU01HL134812 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI DALEY, GEORGE Q, LIPTON, JEFFREY M · 2016 to 2022
$8.3MMolecular Circuits in the Hematopoietic Stem Cell NicheRC2DK120535 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI COLLINS, JAMES J, DALEY, GEORGE Q · 2020 to 2024
$8.2MA Community Zebrafish Resource for Modeling GWAS BiologyR24OD017870 · OD · BRIGHAM AND WOMEN'S HOSPITAL · PI GOESSLING, WOLFRAM, MACRAE, CALUM A. · 2014 to 2021
$6.3MThe role of clonal hematopoiesis in the development and therapy of myeloid malignanciesR35CA253125 · NCI · DANA-FARBER CANCER INST · PI EBERT, BENJAMIN LEVINE · 2020 to 2024
$4.9MTranscriptional response to signaling during hematopoiesisR01HL144780 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI ZON, LEONARD IRA · 2019 to 2022
$2.1MRole of noncoding RNA decay in glucose homeostasisK01DK121861 · NIDDK · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI PIROUZ, MEHDI · 2020 to 2021
$309kCharacterization of Calmodulin and CHK2 inhibitors for the treatment of Diamond BF32HL124948 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI MACARI, ELIZABETH R · 2014 to 2016
$111kHoward Hughes Medical InstituteNCI NIH HHS R35 CA253125NHLBI NIH HHS F32 HL124948NHLBI NIH HHS P01 HL032262NHLBI NIH HHS P01 HL131477NHLBI NIH HHS R01 HL144780NHLBI NIH HHS U01 HL100001NHLBI NIH HHS U01 HL134812NIDDK NIH HHS K01 DK121861NIDDK NIH HHS R24 DK092760NIDDK NIH HHS RC2 DK120535NIH HHS R24 OD017870
Abstract
Diamond-Blackfan anemia (DBA) is a rare hematopoietic disease characterized by a block in red cell differentiation. Most DBA cases are caused by mutations in ribosomal proteins and characterized by higher than normal activity of the tumor suppressor p53. Higher p53 activity is thought to contribute to DBA phenotypes by inducing apoptosis during red blood cell differentiation. Currently, there are few therapies available for patients with DBA. We performed a chemical screen using zebrafish ribosomal small subunit protein 29 (
Indexed as
Anemia, Diamond-BlackfanAnimalsApoptosisCalmodulinErythropoiesisHumansTumor Suppressor Protein p53ZebrafishCalmodulinTumor Suppressor Protein p53
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.