Evidence map›Paper›PMID 33087495›Full record

ArticleNeurology2021

CT-Visible Convexity Subarachnoid Hemorrhage is Associated With Cortical Superficial Siderosis and Predicts Recurrent ICH.

Qi Li, Maria Clara Zanon Zotin, Andrew D Warren, Yuan Ma, Edip Gurol, Joshua N Goldstein, Steven M Greenberg, Andreas Charidimou, Nicolas Raposo, Anand Viswanathan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Association ofStroke and vascular neurology · 2025
    Article
  6. Article
  7. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Qi LiFrom the Department of Neurology (Q.L., M.C.Z.Z., A.D.W., E.G., S.M.G., A.C., A.V.) and Division of Neurocritical Care and Emergency Neurology (J.N.G.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurology (Q.L.), The First Affiliated Hospital of Chongqing Medical University, China; Department of Epidemiology (Y.M.), Harvard T.H. Chan School of Public Health, Boston, MA; and Department of Neurology (N.R.), Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse, France. qili_md@126.com.
Maria Clara Zanon ZotinFrom the Department of Neurology (Q.L., M.C.Z.Z., A.D.W., E.G., S.M.G., A.C., A.V.) and Division of Neurocritical Care and Emergency Neurology (J.N.G.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurology (Q.L.), The First Affiliated Hospital of Chongqing Medical University, China; Department of Epidemiology (Y.M.), Harvard T.H. Chan School of Public Health, Boston, MA; and Department of Neurology (N.R.), Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse, France.
Andrew D WarrenFrom the Department of Neurology (Q.L., M.C.Z.Z., A.D.W., E.G., S.M.G., A.C., A.V.) and Division of Neurocritical Care and Emergency Neurology (J.N.G.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurology (Q.L.), The First Affiliated Hospital of Chongqing Medical University, China; Department of Epidemiology (Y.M.), Harvard T.H. Chan School of Public Health, Boston, MA; and Department of Neurology (N.R.), Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse, France.
Yuan MaFrom the Department of Neurology (Q.L., M.C.Z.Z., A.D.W., E.G., S.M.G., A.C., A.V.) and Division of Neurocritical Care and Emergency Neurology (J.N.G.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurology (Q.L.), The First Affiliated Hospital of Chongqing Medical University, China; Department of Epidemiology (Y.M.), Harvard T.H. Chan School of Public Health, Boston, MA; and Department of Neurology (N.R.), Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse, France.
Edip GurolFrom the Department of Neurology (Q.L., M.C.Z.Z., A.D.W., E.G., S.M.G., A.C., A.V.) and Division of Neurocritical Care and Emergency Neurology (J.N.G.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurology (Q.L.), The First Affiliated Hospital of Chongqing Medical University, China; Department of Epidemiology (Y.M.), Harvard T.H. Chan School of Public Health, Boston, MA; and Department of Neurology (N.R.), Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse, France.
Joshua N GoldsteinFrom the Department of Neurology (Q.L., M.C.Z.Z., A.D.W., E.G., S.M.G., A.C., A.V.) and Division of Neurocritical Care and Emergency Neurology (J.N.G.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurology (Q.L.), The First Affiliated Hospital of Chongqing Medical University, China; Department of Epidemiology (Y.M.), Harvard T.H. Chan School of Public Health, Boston, MA; and Department of Neurology (N.R.), Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse, France.
Steven M GreenbergFrom the Department of Neurology (Q.L., M.C.Z.Z., A.D.W., E.G., S.M.G., A.C., A.V.) and Division of Neurocritical Care and Emergency Neurology (J.N.G.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurology (Q.L.), The First Affiliated Hospital of Chongqing Medical University, China; Department of Epidemiology (Y.M.), Harvard T.H. Chan School of Public Health, Boston, MA; and Department of Neurology (N.R.), Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse, France.
Andreas CharidimouFrom the Department of Neurology (Q.L., M.C.Z.Z., A.D.W., E.G., S.M.G., A.C., A.V.) and Division of Neurocritical Care and Emergency Neurology (J.N.G.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurology (Q.L.), The First Affiliated Hospital of Chongqing Medical University, China; Department of Epidemiology (Y.M.), Harvard T.H. Chan School of Public Health, Boston, MA; and Department of Neurology (N.R.), Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse, France.
Nicolas RaposoFrom the Department of Neurology (Q.L., M.C.Z.Z., A.D.W., E.G., S.M.G., A.C., A.V.) and Division of Neurocritical Care and Emergency Neurology (J.N.G.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurology (Q.L.), The First Affiliated Hospital of Chongqing Medical University, China; Department of Epidemiology (Y.M.), Harvard T.H. Chan School of Public Health, Boston, MA; and Department of Neurology (N.R.), Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse, France.ORCID 0000-0002-9152-4445
Anand ViswanathanFrom the Department of Neurology (Q.L., M.C.Z.Z., A.D.W., E.G., S.M.G., A.C., A.V.) and Division of Neurocritical Care and Emergency Neurology (J.N.G.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurology (Q.L.), The First Affiliated Hospital of Chongqing Medical University, China; Department of Epidemiology (Y.M.), Harvard T.H. Chan School of Public Health, Boston, MA; and Department of Neurology (N.R.), Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse, France.
Harvard University · US

Funding

Vascular Dysfunction in Cerebral Amyloid AngiopathyR01AG026484 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GREENBERG, STEVEN M · 2005 to 2019
$7.5M
Vascular Pathology in Early and Asymptomatic Cerebral Amyloid AngiopathyR01AG047975 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI VISWANATHAN, ANAND · 2014 to 2025
$7.5M
Early Detection of Cerebral Amyloid AngiopathyR01NS070834 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI GREENBERG, STEVEN M · 2010 to 2014
$2.3M
NIA NIH HHS R01 AG026484NIA NIH HHS R01 AG047975NINDS NIH HHS R01 NS070834
6 · The paper itself

Abstract

objectiveTo investigate whether acute convexity subarachnoid hemorrhage (cSAH) detected on CT in lobar intracerebral hemorrhage (ICH) related to cerebral amyloid angiopathy (CAA) is associated with recurrent ICH.

methodsWe analyzed data from a prospective cohort of consecutive acute lobar ICH survivors fulfilling the Boston criteria for possible or probable CAA who had both brain CT and MRI at index ICH. Presence of cSAH was assessed on CT blinded to MRI data. Cortical superficial siderosis (cSS), cerebral microbleeds, and white matter hyperintensities were evaluated on MRI. Cox proportional hazard models were used to assess the association between cSAH and the risk of recurrent symptomatic ICH during follow-up.

resultsA total of 244 ICH survivors (76.4 ± 8.7 years; 54.5% female) were included. cSAH was observed on baseline CT in 99 patients (40.5%). Presence of cSAH was independently associated with cSS, hematoma volume, and preexisting dementia. During a median follow-up of 2.66 years, 49 patients (20.0%) had recurrent symptomatic ICH. Presence of cSAH was associated with recurrent ICH (hazard ratio 2.64; 95% confidence interval 1.46-4.79;

conclusioncSAH was detected on CT in 40.5% of patients with acute lobar ICH related to CAA and heralds an increased risk of recurrent ICH. This CT marker may be widely used to stratify the ICH risk in patients with CAA. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that cSAH accurately predicts recurrent stroke in patients with CAA.

Indexed as

AgedAged, 80 and overBrainFemaleHumansMagnetic Resonance ImagingMalePredictive Value of TestsProspective StudiesRecurrenceSiderosisSubarachnoid HemorrhageTomography, X-Ray ComputedWhite Matter

Identifiers

PMID33087495
PMCPMC8055336
OpenAlexW3094377062

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.